Alcohol Drinking Clinical Trial
Official title:
Comparative Study on Development of Paradoxical Excitement Response During Sedation Using Dexmedetomidine or Propofol in Hazardous Alcohol Drinkers
1. Adequate sedation with classical sedative agents, propofol
2. Sedation with propofol may induce paradoxical excitement response in heavy alcohol
drinkers
3. Dexmedetomidine, α2 receptor agonist, may provide adequate sedation in heavy alcohol
drinkers
1. Adequate sedation during surgery provide anxiolysis and comfort to patient. Insufficient
sedation can't provide comfort to patient during surgery, otherwise excessive sedation
can cause variable complications like respiratory depression or delayed awakening.
2. Dexmedetomidine is a centrally acting α2 receptor agonist that is increasingly being
used as a sedative for MAC and intensive care with mechanical ventilated patients
because of its analgesic properties, "cooperative sedation," and lack of respiratory
depression.
3. Because of the different site of action between dexmedetomidine and propofol, we assumed
that paradoxical excitement responses which appeared in heavy alcohol drinkers in
midazolam or propofol-induced sedation might be less observed in dexmedetomidine-induced
sedation.
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