Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?

Status Recruiting

Clinical Trial Summary

For this protocol, the investigators plan to conduct a pilot study evaluating the effect of propranolol on alcohol consumption. Using a parallel design, the investigators plan to randomize 20 non-treatment seeking adults with alcohol use disorders (DSM-5) to propranolol extended release (160mg/day or placebo; n=10 per cell) to evaluate whether propranolol reduces alcohol self-administered in the laboratory. Importantly, the investigators will evaluate whether propranolol counteracts stress-induced effects on alcohol self-administration. Following titration to steady state medication levels over a 2-week period, each subject will complete two laboratory sessions consisting of a well validated method for inducing stress or neutral/relaxing state (order counterbalanced), followed by a 2-hour alcohol self-administration paradigm known to be sensitive to medication effects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Alcohol Drinking

Clinical Trial Details

NCT number	NCT03588754
Study type	Interventional
Source	Yale University
Contact	Sabrina Coppola
Phone	203-737-2827
Email	sabrina.coppola@yale.edu
Status	Recruiting
Phase	Phase 2
Start date	September 15, 2018
Completion date	February 28, 2025

View Details

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