Clinical Trials Logo

Clinical Trial Summary

The effects of desflurane versus sevoflurane in adult patients undergoing LMA anesthesia on respiratory events during a less than 2-hour elective surgery.


Clinical Trial Description

Laryngeal Mask Airway (LMA) anesthesia is generally performed for ambulatory surgery to avoid the use of neuromuscular blocking agents and to facilitate rapid emergence from anesthesia. Inhaled anesthetics are simply and popularly used during maintenance of anesthesia. The two most recent volatile anesthetic agents, desflurane and sevoflurane, are the two most commonly used in clinical practice for an ambulatory setting.

Desflurane is the volatile agent with low blood: gas partition coefficient (0.42). Desflurane's uptake and elimination from the body of a patient are rapid, which results in a fast onset of anesthesia and a fast recovery from anesthesia. This property provides desflurane as an ideal agent for the ambulatory anesthesia. However, its pungent odor is concerned to irritate the upper airway and may cause significant respiratory complications. Sevoflurane has a blood: gas partition coefficient of 0.65, which is slightly greater than desflurane. The major advantage over desflurane is the better scent. It is considered to be less airway irritation in LMA anesthesia with smooth induction and recovery.

The limitation of desflurane on its odor leads to a controversy if desflurane is similar to or worse than sevoflurane for LMA anesthesia. This is non-inferiority study designed to compare the occurrence of respiratory complications between desflurane and sevoflurane during LMA anesthesia. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03006250
Study type Interventional
Source Chiang Mai University
Contact Pathomporn Pin-on, M.D.
Phone 66-86-897-0009
Email [email protected]
Status Recruiting
Phase Phase 4
Start date August 2016
Completion date July 2019

See also
  Status Clinical Trial Phase
Completed NCT02823392 - Difficult Bag Mask Ventilation and Difficult Intubation in Children
Recruiting NCT03839784 - Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Recruiting NCT03109119 - Does Sevoflurane Cause Genomic Damage Phase 4
Recruiting NCT04604106 - General Anesthesia Exposure and Neurodevelopmental Outcome in Pediatrics
Enrolling by invitation NCT04322994 - THRIVE Use in Pediatric Populations- Multi Site N/A
Completed NCT03394833 - Hemodynamic Stability During Induction of Anaesthesia N/A
Not yet recruiting NCT04797312 - Comparison of an Opioid-Free Anesthesia Protocol Versus Standard Practices on Early and Late Post-operative Recovery Phase 3
Completed NCT04284644 - Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques N/A
Completed NCT03833947 - Dexamethasone vs Bicarbonate to Intracuff Lignocaine 2% in General Anaesthesia Phase 4
Active, not recruiting NCT04275531 - Neurotoxicity of Anesthesia in Middle Aged Patients
Recruiting NCT04087668 - Different Anesthetic Technique For ERCP N/A
Completed NCT04455776 - Safety Evaluation of Propofol Sedation for Magnetic Resonance Imaging in Pediatric Patients
Recruiting NCT04377633 - Anesthesia-handover Checklist and Perioperative Outcomes in Elderly N/A
Completed NCT02976584 - Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome
Completed NCT02062333 - The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea Phase 4
Completed NCT03967496 - Assessment of Immediate Postoperative Delirium (IPD) in Adult Patients: Incidence and Etiologic Factors
Recruiting NCT03383770 - Dual Guidance in Regional Anesthesia N/A
Completed NCT03430206 - Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures N/A
Recruiting NCT03318133 - Comparison of CLSB With Sedation Versus General Endotracheal Anesthesia on Postoperative Outcomes in Elderly Patients Undergoing Hip Fracture Surgery N/A
Recruiting NCT04679818 - Intraoperative NOL Titration Phase 3