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Anencephaly clinical trials

View clinical trials related to Anencephaly.

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NCT ID: NCT06174883 Completed - Spina Bifida Clinical Trials

Salt-FA to Increase Folate Levels

Start date: June 1, 2022
Phase:
Study type: Observational

Question: How effective is folic acid-fortified iodized salt in increasing serum folate concentrations among non-pregnant and non-lactating women of reproductive age? Hypothesis: Folic acid-fortified iodized salt can increase serum folate levels and serve as a policy consideration in salt fortification with both iodine and folic acid to reduce serious and fatal birth defects.

NCT ID: NCT05455814 Recruiting - Meditation Clinical Trials

Brain Health With Inner Engineering Meditation

BLISS
Start date: January 6, 2023
Phase: N/A
Study type: Interventional

This study will explore whether a 21-minute meditation practice called Shambhavi Mahamudra Kriya leads to changes in brain health and explore how it affects cognitive and physiological function.

NCT ID: NCT04303845 Terminated - Hemicrania Continua Clinical Trials

Erenumab For Treatment of Hemicrania Continua

Start date: August 4, 2021
Phase: Phase 2
Study type: Interventional

This research is being conducting to learn if the study drug erenumab is successful in treating hemicrania continua. The study is also evaluating the safety and tolerability of erenumab in individuals being treated for hemicrania continua.

NCT ID: NCT03511846 Active, not recruiting - Migraine Clinical Trials

Pain Biomarker Study

PBS
Start date: March 21, 2018
Phase: Phase 1
Study type: Interventional

This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1. Use of capsaicin (active ingredient in hot chili peppers) to trigger release of calcitonin gene related peptide - the hypothesis is that this will be different in headache subjects compared to controls (and if so might be used to predict how these patients will respond to certain medications that modulate calcitonin gene-related peptide). Subjects will be given capsaicin as a cream applied to the forehead or the inner nostril, or a hot sauce that is ingested. 2. Use of capsaicin to trigger eye watering - the hypothesis is that oxygen gas will slow down the amount of eye watering. Cluster headache patients respond very powerfully to oxygen gas but to very little else. The mechanism for oxygen is unknown but in rodents there is data that it works on the parasympathetic / lacrimal gland system. This study translates rodent data into humans in a non-invasive way to confirm the mechanism of this very effective treatment. 3. Use of ice water to trigger headaches - brain freeze causes a very short-lived but intense headache that may cause similar biomarker release as other headache disorders. This may be a useful human model for other headache disorders.

NCT ID: NCT02910323 Recruiting - Clinical trials for Trigeminal Neuralgia

The Will Erwin Headache Research Center - Cluster Headache Study

WEC1
Start date: May 2016
Phase:
Study type: Observational

The Will Erwin Headache Research Center Study of Cluster Headache and Trigeminal Neuralgia is a prospective, multicenter, observational research network for subjects with Cluster Headache and/or Trigeminal Neuralgia.

NCT ID: NCT00636233 Completed - Anencephaly Clinical Trials

Genetics of Spina Bifida and Anencephaly

Start date: May 1993
Phase:
Study type: Observational

The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly. Ultimately, this type of research may result in improved diagnosis, improved treatment and possibly prevention.

NCT ID: NCT00207558 Completed - Clinical trials for Neural Tube Defects - Spina Bifida and Anencephaly

Blood Folate and Homocysteine Levels Following Administration of Folic Acid According to Different Daily Dosing Schedules:a Simulation of Food Fortification

Start date: n/a
Phase: N/A
Study type: Interventional

The aim of this study is to examine whether the same total daily dosage of folic acid, when taken as a single daily dose or as multiple divided doses throughout the day, results in different blood folate and homocysteine levels at the conclusion of the study. Further, a comparison of blood folate and homocysteine levels among women taking daily low-dosage (100mcg) and standard- dosage (400mcg) folic acid with those of women taking daily or weekly high-dosage (4000mcg) folic acid will be conducted.

NCT ID: NCT00207532 Completed - Clinical trials for Spina Bifida and Anencephaly

Dosage Effects of Folic Acid on Blood Folates of Honduran Women

Start date: March 2005
Phase: N/A
Study type: Interventional

CDC staff at the National Center on Birth Defects and Developmental Disabilities have been working closely with a Honduras-based organization, Project Healthy Children (PNS) and the Ministry of Health, on a folic acid supplementation study among female maquila workers. Participants are divided into two groups. One group receives a 1.0 milligram pill daily while the other group receives a 5.0 milligram pill weekly. The aim of this study is to assess serum blood folate levels measured at baseline, midpoint, and endpoint of the study. Hypothesis: Folic acid (5mg)given once weekly is as effective as folic acid (1mg)given daily in raising blood folate levels.

NCT ID: NCT00031122 Active, not recruiting - Spina Bifida Clinical Trials

Study of Genetic Risk Factors for Spina Bifida and Anencephaly

SBRR
Start date: September 2000
Phase: N/A
Study type: Observational

The purpose of this study is to describe the genetic contribution to the neural tube defects spina bifida (SB) and anencephaly (A), which includes identifying patients, defining the roles of certain genes, and studying gene-environment interactions.