Clinical Trials Logo

Alzheimer Disease clinical trials

View clinical trials related to Alzheimer Disease.

Filter by:

NCT ID: NCT03823066 Completed - Dementia Clinical Trials

Experience With a Robot for Home Care and Its Acceptance by People With Dementia, Caregivers and Dementia Trainers

Start date: August 22, 2018
Phase: N/A
Study type: Interventional

Background: Dementia rates are increasing worldwide and consequently burden global healthcare resources to a serious degree. However, there is a declining number of caregivers to provide care. It is for this reason that many new technologies, such as socially assistive robots, have been developed because of their potential to support caregivers in promoting the independence of people with dementia. Most of the (socially assistive) robots have so far been tested for people without dementia in mainly laboratory or institutional settings, like nursing homes. Consequently, there is a lack of knowledge about the possible uses of robots from the perspective of those affected by dementia in real-life/care situations (e.g. at home). Testing in a laboratory setting cannot capture the complexity and high variability of everyday situations occurring during the care of persons with dementia. Methods The design is a mixed method intervention study of a refined socially assistive humanoid robot. In total, three people with dementia, three relatives, three dementia trainers and three professional caregivers were included in the study. Quantitative data of technology acceptance were collected using the "Technology Usage Inventory". Qualitative data (main focus: experiences with the robot and handling the robot) were collected by means of observation and qualitative interviews. Movement data of people with dementia were collected by means of the eye camera of the robot. This study helps to further refine and test a socially assistive robot for people with dementia living at home.

NCT ID: NCT03822208 Completed - Healthy Clinical Trials

First in Human Study for Safety and Tolerability of AL003.

Start date: March 29, 2019
Phase: Phase 1
Study type: Interventional

This is a multi-center, randomized, double-blind, placebo-controlled, dose escalation first in human (FIH) study in healthy adults and in patients with mild to moderate Alzheimer's disease. The study is designed to systematically assess the safety (including immunogenicity) and tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AL003.

NCT ID: NCT03821844 Completed - Dementia Clinical Trials

Music & MEmory: A Pragmatic TRial for Nursing Home Residents With ALzheimer's Disease_part1

METRIcAL
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The purpose of this trial is to test the effects of a personalized music intervention (Music and Memory, Inc.) on agitated and aggressive behaviors for nursing home residents with dementia.

NCT ID: NCT03811847 Completed - Alzheimer Dementia Clinical Trials

A Pilot of Methylphenidate in Mild Cognitive Impairment and Dementia Participants.

Start date: November 1, 2019
Phase: Phase 4
Study type: Interventional

Investigators are doing this research study to find out if methylphenidate (MPH) can help people with Mild Cognitive Impairment (MCI) or mild dementia likely due to Alzheimer's Disease (AD) and related disorders (ADRD). The study drug MPH is approved by the U.S. Food and Drug Administration (FDA) to treat Attention Deficit/Hyperactivity Disorder (ADHD), but MPH is not approved by the FDA to treat Mild Cognitive Impairment or mild dementia related to Alzheimer's Disease. However, other studies have been done in which MPH has been given to people with neurodegenerative dementias and results have shown some improvement in these people's mood and cognition. Investigators would like to see if MPH will help mood and cognition. This study will take place completely virtually (with the option to come in for the first visit to meet the study team). All study visits will occur over a secure videoconferencing platform. All study materials will be shipped directly to the home of each participant.

NCT ID: NCT03802162 Completed - Clinical trials for Alzheimer's Disease (AD)

A Clinical Study to Evaluate the Pharmacokinetics, Safety and Tolerability of CKD-355

Start date: February 15, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the pharmacokinetics, safety and tolerability of CKD-355.

NCT ID: NCT03801642 Completed - Alzheimer Disease Clinical Trials

Dapagliflozin In Alzheimer's Disease

Start date: January 29, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is a pilot randomized controlled trial in individuals with probable Alzheimer's disease testing the effects of 10 mg dapagliflozin, taken daily for 12 weeks, on cerebral n-acetyl aspartate (NAA) levels using magnetic resonance spectroscopy (MRS). The investigators will also examine the safety and tolerability of dapagliflozin and explore the effects on systemic NAA levels in blood and urine, cerebral metabolism (fluorodeoxyglucose [FDG] PET), systemic metabolic biomarkers that indicate and quantify secondary metabolic effects, and cognitive performance.

NCT ID: NCT03794141 Completed - Health Behavior Clinical Trials

Genetic Information as a Life Style Change Motivator

APOE4MOT
Start date: January 2, 2017
Phase: N/A
Study type: Interventional

The study investigates whether information on having a risk genotype (ApoE4) and life style advisory information affects lifestyle changes and sensory preferences. The project studies also the ethic aspects of giving the information of risk genotype.

NCT ID: NCT03790709 Completed - Alzheimer Disease Clinical Trials

ANAVEX2-73 for Treatment of Early Alzheimer's Disease

Start date: July 3, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

Phase 2b/3 48-week study to evaluate the effects of ANAVEX2-73 on cognition and function after 48 weeks of daily treatment. Additional outcome measures include refined measures of sleep, behavioral and psychological symptoms typically observed in AD, changes in daily functioning of participants and changes in caregiver burden, as well as changes in quality of life measures of both, patients and caregivers during treatment with ANAVEX2-73.

NCT ID: NCT03786510 Completed - Alzheimer Disease Clinical Trials

A Study on the Effectiveness of Multidomain Intervention Program for Reducing Risks of Dementia

Start date: November 1, 2016
Phase: N/A
Study type: Interventional

Investigators aimed to examine the feasibility and effectiveness of a multidomain intervention strategy involving intensive and maintenance programs aimed at reducing the risk of Alzheimer's disease (AD) in at-risk older adults. Participants were randomly allocated into three groups: (1) intensive plus maintenance program (INT+MNT group), (2) intensive program only (INT-only group), and (3) active control (control group). There were two study hypotheses: 1) the participants in the 4-week intensive program (INT+MNT and INT-only group) would show reduced dementia risk scores compared to control; and 2) that the participants in the added 20-week maintenance program (INT+MNT group) would show greater improvement in dementia risk scores compared to the INT-only and control groups.

NCT ID: NCT03784300 Completed - Alzheimer Disease Clinical Trials

A Safety Study of PTI-125 in Healthy Volunteers

Start date: August 18, 2017
Phase: Phase 1
Study type: Interventional

A Phase I, Single Center, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose, Pharmacokinetic and Safety Study of PTl-125 in Healthy Volunteers