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Altitude clinical trials

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NCT ID: NCT05037032 Completed - Clinical trials for Sleep Apnea, Central

Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude

Start date: August 8, 2021
Phase: Phase 4
Study type: Interventional

Sleep at altitude is often poor. The purpose of this study is to evaluate the effects of a single dose of the opioid antagonist, naltrexone, on sleep quality and periodic breathing after rapid ascent to ~3800m altitude.

NCT ID: NCT04075565 Completed - Hypoxia Clinical Trials

The Psychophysiological Effect of Simulated and Terrestrial Altitude

Hypoxia
Start date: June 24, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.

NCT ID: NCT03710369 Completed - Exercise Clinical Trials

Endurance Performance at Altitude

Start date: November 1, 2015
Phase: N/A
Study type: Interventional

The degree to which endurance exercise performance is diminished in acute hypoxia is variable and appears to be the result of several different physiological processes, however this research focuses on hypoxic pulmonary vasoconstriction (HPV). Sildenafil, a pulmonary vasodilator, has been used with mixed results to improve athletic performance in hypoxia. Because sildenafil has been shown to reduce HPV in some individuals, we believe that its effectiveness is closely related to the magnitude of the HPV response and the degree that individual exercise performance declines in hypoxia. This research will investigate the relationship between sildenafil, HPV, and exercise performance.

NCT ID: NCT02237274 Completed - Fontan Procedure Clinical Trials

Cardiopulmonary Adaptation of Short Term Exposure to High Altitude in Fontan Patients: Swiss Fontan & ALtitude COllaboratioN (FALCON) Study

FALCON
Start date: July 2014
Phase: N/A
Study type: Interventional

Important advances in cardiac surgery, intensive care, and diagnostic modalities over the last decades have led to a steady growth in the number of adults with congenital heart defects. Among adults with congenital heart disease, patients with a Fontan circulation typically show the lowest values of peak oxygen consumption. For these patients, strict exclusion from activities at high altitude may have an impact on quality of life. The investigators aim to elucidate the short term effects of a stay at high altitude on hemodynamic adaptation, exercise capacity and clinical well being in adult Fontan patients. The investigators hypothesize that patients with a Fontan circulation in NYHA functional class I-II are able to increase their cardiac output during exercise at high altitude in order to meet the required metabolic demands and therefore tolerate the journey to the Jungfraujoch well.

NCT ID: NCT01245114 Completed - Hypoxia Clinical Trials

Tübingen High Altitude Ophthalmology Study

THAO
Start date: n/a
Phase: N/A
Study type: Observational

Tuebingen High Altitude Ophthalmology Study to investigate the effects of high altitude on retinal structure and function as well as anterior chamber in regard to acute mountain sickness.

NCT ID: NCT00924833 Completed - Heart Failure Clinical Trials

Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects.

Start date: May 2006
Phase: Phase 4
Study type: Interventional

Exposure of healthy subjects to high altitude hypoxia elicits changes in cardiovascular, respiratory and metabolic features as weel as in exercise performance similar, for some aspects, to those observed in chronic heart failure. Exposure to high altitude hypoxia represents a suitable model to assess different treatments proposed for this pathological condition. Our aim was to evaluate the impact of two different third-generation beta-blockers used in heart failure (carvedilol and nebivolol) on cardiovascular, respiratory, metabolic profile and on exercise performance at high altitude.

NCT ID: NCT00685438 Completed - Oxidative Stress Clinical Trials

Ultraviolet Exposure, Antioxidant Use and Skin Erythema at Extreme High Altitude

Start date: April 2007
Phase: N/A
Study type: Observational

With the increasing tourism and adventure travel into extreme environments comes the need to reassess the required protection against ultraviolet (UV) radiation and possible other oxidative stresses. This is an observational study of UV radiation exposure and skin erythema while at extreme altitude (Mt. Everest). In addition to UV exposure, skin erythema, antioxidant use (such as vitamins C and E) will be measured. Hypothesis: 1. UV radiation at extreme altitude has larger effects on the skin than at sea level; therefore requiring an adjustment of the antioxidant use for adequate protection. 2. The skin is an accurate reflection of UV and oxidative stress exposure 3. The efficacy of oxidatives stress is reflective of the ethnicity of the individual.

NCT ID: NCT00498563 Completed - Hypoxia Clinical Trials

Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance

Start date: October 2006
Phase: N/A
Study type: Interventional

Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep. Sleep deprivation is associated with degraded post-sleep performance of neurobehavioral tasks. The lowest altitude at which sleep and/or post-sleep performance are affected is not known. The study hypothesis is that sleep and/or post-sleep performance of neurobehavioral tasks will occur due to hypobaric hypoxia at altitudes of 8,000 or less.

NCT ID: NCT00432978 Completed - Clinical trials for Pulmonary Hypertension

Effect of Bosentan on Exercise Capacity at High Altitude

Start date: July 2006
Phase: Phase 1
Study type: Interventional

This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.