Enhancing Prospective Thinking in Early Recovery (BEAM)

Alcohol Use Disorder Clinical Trial

— BEAM  

Official title:

Enhancing Prospective Thinking in Early Recovery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06283472
• Other study ID #: 1805574553; Aims 14-16
• Secondary ID: 2P60AA007611-403
• Status: Recruiting
• Phase: N/A
• Start date: June 1, 2024
• Est. completion date: February 1, 2027

Study information

• Verified date: June 2024
• Source: Indiana University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question[s] this trial aims to answer are:

• Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?

• Will high-intensity EFT cues effect greater treatment-seeking interest?

• Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)

• Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?

• Will the novel behavioral SS decision-making task activate the nucleus accumbens?

Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 150
• Est. completion date: February 1, 2027
• Est. primary completion date: February 1, 2027
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Individuals who meet current heavy drinking (=2 heavy drinking days/month OR =7 drinks/week for biological females, and =14 drinks/week if biological male [NIAAA definition] and/or AUDIT scores =8)

• English comprehension

Exclusion Criteria:

• Unstable medical disorders

• Outside the age range of 18-60

• Smell/taste disorders

• Unstable psychiatric conditions

Related Conditions & MeSH terms

• Alcohol Drinking
• Alcohol Use Disorder
• Alcoholism

Intervention

Behavioral:
• High-Intensity Cue
Participants in the high-intensity group will receive high-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.
• Low-Intensity Cue
Participants in the low-intensity group will receive low-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.

Locations

Country	Name	City	State
United States	Indiana University School of Medicine - Goodman Hall	Indianapolis	Indiana

Sponsors (1)

Lead Sponsor	Collaborator
Indiana University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Increase Prospective Thinking	High-intensity episodic future-thinking image cues will change prospective thinking.	Study Day Visit (Day 1)
Primary	Delayed Rewards	High-intensity episodic future-thinking image cues will change preference for delayed rewards, which will be measured using a behavioral delayed discounting task.	Study Day Visit (Day 1)