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Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker — DEX  

Alcohol Drinking Clinical Trial

Official title:
Comparative Study on Development of Paradoxical Excitement Response During Sedation Using Dexmedetomidine or Propofol in Hazardous Alcohol Drinkers

Clinical Trial Summary

1. Adequate sedation with classical sedative agents, propofol

2. Sedation with propofol may induce paradoxical excitement response in heavy alcohol drinkers

3. Dexmedetomidine, α2 receptor agonist, may provide adequate sedation in heavy alcohol drinkers

Clinical Trial Description

1. Adequate sedation during surgery provide anxiolysis and comfort to patient. Insufficient sedation can't provide comfort to patient during surgery, otherwise excessive sedation can cause variable complications like respiratory depression or delayed awakening.

2. Dexmedetomidine is a centrally acting α2 receptor agonist that is increasingly being used as a sedative for MAC and intensive care with mechanical ventilated patients because of its analgesic properties, "cooperative sedation," and lack of respiratory depression.

3. Because of the different site of action between dexmedetomidine and propofol, we assumed that paradoxical excitement responses which appeared in heavy alcohol drinkers in midazolam or propofol-induced sedation might be less observed in dexmedetomidine-induced sedation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02197403
Study type Interventional
Source Chonnam National University Hospital
Contact
Status Recruiting
Phase Phase 4
Start date December 2013
Completion date May 31, 2019
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