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Alcohol Drinking clinical trials

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NCT ID: NCT03658330 Completed - Clinical trials for Major Depressive Disorder

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

Start date: May 2016
Phase: Phase 2
Study type: Interventional

To evaluate if naltrexone plus ketamine is effective in reducing depression and alcohol consumption.

NCT ID: NCT03625492 Completed - Overactive Bladder Clinical Trials

Fluids Affecting Bladder Urgency and Lower Urinary Symptoms

FABULUS
Start date: August 7, 2018
Phase: N/A
Study type: Interventional

This study evaluates whether eliminating certain ingredients (caffeine, alcohol, artificial sweeteners, acidic juices) consumed in beverages reduces bladder symptoms of urinary frequency and urgency. Women with overactive bladder will be recruited. Half of these women will receive instructions to replace beverages containing these ingredients with beverages such as water or milk. The other half of participants will receive instructions on following the United States Department of Agriculture guidelines on healthy eating.

NCT ID: NCT03610633 Completed - Clinical trials for Alcohol Use Disorder

Oxytocin and Stress Response in Alcohol Use Disorder

Start date: March 2016
Phase: Phase 2
Study type: Interventional

Individuals with alcohol use disorder (AUD) will complete one functional Magnetic Resonance Imaging (fMRI) scanning visit. Prior to the scan, individuals will receive a nasal spray of either 24 international units (IU) of oxytocin (OT), or placebo (PBO). During the scan, they will perform the Montreal Imaging Stress Task (MIST), a social stress task. Subjective craving and anxiety data will be collected.

NCT ID: NCT03607318 Completed - Alcohol Drinking Clinical Trials

Brief Alcohol Intervention and mHealth Booster for Suicidal Adolescents

Start date: June 18, 2018
Phase: N/A
Study type: Interventional

The primary goal of this study is to test the acceptability and feasibility of iASIST (integrated Alcohol and Suicide Intervention for Suicidal Teens), a novel adjunctive intervention for alcohol use and alcohol-related suicidal thoughts and behaviors for suicidal adolescent inpatients. The investigators will first conduct an open trial with 10 adolescents and their parents to test iASIST and make subsequent changes to the booster. Next, the investigators will conduct a randomized trial with 50 adolescents and their parents to test the feasibility and acceptability of iASIST as well as associations with alcohol- and suicide-related outcomes at 3 months post-discharge, relative to participants who receive an attention-matched comparison condition focused on the role of a healthy lifestyle in mental health that includes a post-discharge mHealth control targeting the maintenance of a healthy lifestyle.

NCT ID: NCT03594435 Completed - Clinical trials for Alcohol Use Disorder

Ibudilast for the Treatment of Alcohol Use Disorder

Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

This study is a double-blind, placebo-controlled randomized clinical trial of IBUD (50mg BID) for the treatment of Alcohol Use Disorder (AUD). Eligible participants will undergo a 12-week medication treatment period and 5 in-person visits over 16 weeks.

NCT ID: NCT03589274 Completed - Clinical trials for Alcohol Use Disorder

Testing CBT Models and Change Mechanisms for Alcohol Dependent Women

WTPIII
Start date: June 1, 2010
Phase: N/A
Study type: Interventional

The study has 4 specific aims: (1) To modify our existing Individual Female Specific Cognitive Behavioral Therapy (I-FS-CBT) for Alcohol Use Disorder (AUD) approach to treat women with alcohol dependence in a group format, Group Female Specific Cognitive Behavioral Therapy (G-FS-CBT); (2) To test the relative efficacy of I-FS-CBT and G-FS-CBT; (3) To test hypothesized mechanisms of change in drinking that are common to both treatments, including (a) coping skills and enhanced self-efficacy for abstinence; (b) enhanced sense of autonomy; (c) alleviation of negative affect, and (d) increased social network support for abstinence, and (4) To assess the relative cost-effectiveness of the individual and group treatment.

NCT ID: NCT03583788 Completed - Clinical trials for Alcohol Use Disorder

Effect of Hypnotherapy in Alcohol Use Disorder Compared to Motivational Interviewing.

Start date: February 1, 2016
Phase: N/A
Study type: Interventional

This study was carried out at an inpatient clinic in Norway. A six- week long treatment programme included intensive group therapy, but also five hours of individual therapy, given as motivational interviewing (MI). Thirty-one patients were randomized either to receive five individual sessions of hypnotherapy instead of MI (N=16) or to be in the control group (N=15). The treatment method for the hypnotherapy group was Erickson`s (permissive) hypnosis. At baseline all the participants were diagnosed using a psychiatric interview and filled in the Alcohol Use Identification Test (AUDIT), Time-line-follow-back (TLFB) for alcohol use, Hopkins Symptoms Check List (HSCL-25) for monitoring mental distress and Traumatic Life Events Questionnaire. AUDIT, TLFB and HSCL-25 were re-administered at follow-up after one year.

NCT ID: NCT03583515 Completed - Alcohol Drinking Clinical Trials

Evaluating Within-Person and Between-Person Effects Of A Personalized Normative Feedback Intervention On Drinking As They Are Moderated By Self-Determination

Start date: April 25, 2018
Phase: N/A
Study type: Interventional

This study evaluates within-person and between-person effects of a personalized normative feedback intervention and injunctive norms as they are altered by self-determination in heavy drinkers. Half of participants will receive personalized normative feedback and the other half will receive control feedback about media use habits.

NCT ID: NCT03575403 Completed - Clinical trials for Alcohol Use Disorder

Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)

BED IN 36
Start date: September 1, 2018
Phase: Phase 1
Study type: Interventional

This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.

NCT ID: NCT03573167 Completed - Clinical trials for Alcohol Use Disorder

Mobile Phone-Based Motivational Interviewing in Kenya

Start date: September 30, 2014
Phase: N/A
Study type: Interventional

The primary objective of this study was to test whether motivational interviewing (MI) provided over the mobile phone would reduce alcohol use among adults, including people living with HIV/AIDS, visiting primary care in Kenya. Heavy alcohol users voluntarily consented to being randomized to one of three study arms: standard in-person MI, mobile MI, or waitlist control receiving no intervention for 1 month followed by mobile MI. Alcohol use problems were assessed using validated screeners and changes in alcohol use were assessed at 1 month and 6 months after receiving the intervention. The investigators hypothesized that alcohol use would reduce after MI treatment compared to waitlist control, there would be no difference between standard in-person MI and mobile MI, and these reductions would be sustained out to six months following the intervention.