Gene Expression Changes In Young and Geriatric Skin

Aging Clinical Trial

Official title:

Gene Expression Changes in Young and Geriatric Skin

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03932162
• Other study ID #: 06694
• Status: Recruiting
• Phase: Early Phase 1
• Start date: September 6, 2019
• Est. completion date: December 2025

Study information

• Verified date: January 2024
• Source: Wright State University
• Contact: Manager, Clinical Research Operations
• Phone: 937-245-7500
• Email: pturesearch[@]wrightstatephysicians.org
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 24
• Est. completion date: December 2025
• Est. primary completion date: December 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years and older

Eligibility

Inclusion Criteria:

• Male/Female
• White skin (Fitzpatrick types I and II)
• Age 21-30 or 65 and older
• Able to comprehend procedures/risks

Exclusion Criteria:

• Known photosensitivity
• Currently on photosensitizing medications
• Diabetes Mellitus
• History of abnormal scarring
• History of skin infections
• Known allergy to lidocaine local anesthetic
• Pregnancy or nursing
• Other serious health issues

Related Conditions & MeSH terms

• Aging
• Insulin-like Growth Factor 1
• UVB Phototherapy Burn

Intervention

Drug:
• Insulin-Like Growth Factor 1
Growth factor protein

Other:
• No Insulin-Lie Growth Factor 1
No Insulin-Like Growth Factor 1 will be given.

Locations

Country	Name	City	State
United States	Wright State Physicians	Fairborn	Ohio

Sponsors (1)

Lead Sponsor	Collaborator
Wright State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline	Expression genes involved in protecting skin cells from UVB damage, including p21, xeroderma pigmentosum (XPC), and polymerase eta, will be higher following UVB exposure in younger skin and geriatric skin injected with IGF-1 than in geriatric skin injected with saline as a control.	2 Days