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Age-Related Sarcopenia clinical trials

View clinical trials related to Age-Related Sarcopenia.

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NCT ID: NCT05964920 Not yet recruiting - Healthy Aging Clinical Trials

Does Human Skeletal Muscle Possess an Epigenetic Memory of Testosterone?

Start date: January 1, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

This project's primary aim of this double-blinded, randomised, placebo-controlled trial is to investigate whether short-term testosterone administration +/- resistance exercise training induces a muscle memory response that can lead to longer-lasting benefits in aged human skeletal muscle. The investigators will provide older men with the anabolic hormone, testosterone or placebo, with or without resistance training, followed by a period of testosterone abstinence and detraining, followed by a subsequent repeated period of resistance training (retraining). This will help determine if earlier encounters with short-term testosterone administration can be "remembered" and if adaptation to later retraining can be enhanced as a consequence of encountering testosterone earlier.

NCT ID: NCT05758792 Completed - Old Age; Debility Clinical Trials

Muscle Quality, Fall Concern and Lower Extremity Functionality in Older Women

Start date: January 20, 2021
Phase:
Study type: Observational

The aim of the study was to investigate the effects of muscle quality on fear of fall, and lower extremity functionality in older women. The differences between muscle quality, fear of falling and lower extremity functionality in the elderly male and female participating in the study were investigated. Older women had worse muscle quality, higher fall concern and less lower extremity functionality than older men.

NCT ID: NCT05542758 Recruiting - Clinical trials for Age-Related Sarcopenia

High-Intensity Interval Training for Older Adults

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

This study will examine differences in a 12 week high-intensity interval training regimen. The Total Body HIIT program incorporates a resistance (circuit) and an anaerobic (bike) component in older adults. The specific objectives focus on examining cardiovascular endurance, neuromuscular function, and muscle architecture.

NCT ID: NCT05420142 Completed - Aging Clinical Trials

Determination of In-vivo Plasma AA Appearance From Plant Protein Fibre Products

Start date: March 14, 2022
Phase: Phase 2
Study type: Interventional

This study aims to assess the digestibility and efficacy of the study groups previously developed innovative plant-based protein and fibre products.

NCT ID: NCT05414292 Recruiting - Muscle Atrophy Clinical Trials

Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)

Rapamune
Start date: August 6, 2021
Phase: N/A
Study type: Interventional

As people age, muscle mass and function is lost and exercise training is an important way to reduce the effects of this and remain independent. However, not everyone can perform this exercise and the muscle responses to exercise are often reduced in older people. So far there has been no drug found to specifically treat or reduce this problem. Muscle size depends on the balance of muscle protein breakdown and synthesis (building). This balance is regulated by multiple signals within the body, but a particular molecule - the mechanistic target of rapamycin (mTOR), is known to play an important role. For protein synthesis to build up the muscles, this pathway is needed to start the process when triggered by eating protein or exercise. Although this would suggest that mTOR activity is good, excessive levels of this signalling seem to have negative impacts on muscle maintenance with age. In animal studies, blocking mTOR signalling has stopped the development of a number of age-related diseases and increased health-span. Drugs that block this pathway (e.g. Rapamune) reduce the stimulation of muscle protein synthesis, possibly through changing the immune system, but conversely have also been shown to increase muscle size and reduce markers of nerve supply loss. This means that drugs which block the mTOR pathway could, in older people, help to reduce the negative impacts of excessive mTOR signalling on muscle size and function. The investigators aim to recruit 16 healthy male volunteers over 50 years old to investigate how the drug Rapamune (which blocks the mTOR pathway) affects aged human muscle both on its own and when combined with resistance exercise training.

NCT ID: NCT05348694 Recruiting - Clinical trials for Glucose Metabolism Disorders

OsteoPreP: Food Supplements for Postmenopausal Bone Health

OsteoPreP
Start date: May 1, 2022
Phase: Phase 4
Study type: Interventional

To evaluate the effect of 12 months of supplementation with a probiotic (probiotic plus prebiotic; 2 capsules per day) on relative change (%) in total volumetric bone density (measured using high resolution peripheral quantitative computed tomography [HR-pQCT]) of the distal tibia.

NCT ID: NCT05060874 Completed - Clinical trials for Age-Related Sarcopenia

Gripwise® Versus JAMAR®

HANDGAGES
Start date: September 1, 2021
Phase:
Study type: Observational

It is recommended to screen ageing patients for sarcopenia, due to the increased risk of morbimortality if detected positive. According to the consensus of the European Working Group on Sarcopenia in Older People, the diagnosis of sarcopenia is based, among other things, on grip strength measurement. Our study will compare the performance of the new GRIPWISE digital device with the mechanical dynamometer JAMAR, the gold standard currently used to assess the grip strength. We propose to evaluate it in an elderly hospitalized population where the prevalence of sarcopenia is likely to be high due to the high prevalence of various chronic illness, notably oncological and cardiological ones. This cross-sectional study will include 348 patients.

NCT ID: NCT04309292 Completed - Sarcopenia Clinical Trials

Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome

PROMOTe
Start date: April 29, 2021
Phase: N/A
Study type: Interventional

Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of muscle occurs with age and skeletal muscle in older adults can display anabolic resistance to protein in diet. It has been hypothesised that the gut microbiome may play a role in this relationship and therefore could be targeted. Aim: This trial aims to test whether modulation of the gut microbiome, in addition to protein supplementation, can improve skeletal muscle function versus protein supplementation alone. Methods: Double blinded, randomised, placebo controlled, dietary intervention study. Twin pairs will be randomised to either receive protein supplementation plus placebo or protein supplementation plus a gut microbiome modulator (prebiotic plus probiotic) for 12 weeks. Primary outcome will be muscle function measured using chair-rise time. Conclusion: Anabolic resistance warrants further characterisation to guide future therapeutic interventions, especially considering its role in the development of disability, sarcopenia and frailty.

NCT ID: NCT04048616 Completed - Muscle Loss Clinical Trials

Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults

Start date: November 1, 2019
Phase: N/A
Study type: Interventional

Whether higher dietary protein benefits skeletal muscle health in older adults remains an ongoing area of investigation. This study will determine whether adding an alkaline salt supplement, potassium bicarbonate, to reduce the dietary acid load of a high protein diet can further enhance the beneficial impact of a high protein diet alone on muscle performance and mass in older underactive adults on baseline low protein diet.