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NCT05124132 Clinical Trial

Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)

Age-related Cognitive Decline Clinical Trial

— MEDEX-2  

Official title:
Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT05124132
Other study ID # 201810006
Secondary ID 1R01AG072694-01A
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date April 16, 2019
Est. completion date August 2026

Study information
Verified date March 2024
Source Washington University School of Medicine
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 468
Est. completion date August 2026
Est. primary completion date August 2026
Accepts healthy volunteers No
Gender All
Age group 65 Years and older
Eligibility Inclusion Criteria: - Participated in the parent study, Protocol ID #201410093 Exclusion Criteria: - Inability to safely continue classes or complete assessments, as per PI discretion

Study Design

Related Conditions & MeSH terms

Intervention

Behavioral:
• Mindfulness-Based Stress Reduction
Mindfulness-Based Stress Reduction
• Exercise
Exercise
• Mindfulness-Based Stress Reduction + Exercise
Mindfulness-Based Stress Reduction + Exercise
• Health Education
Health Education

Locations
Country Name City State
United States Washington University School of Medicine Saint Louis Missouri

Sponsors (4)
Lead Sponsor Collaborator
Washington University School of Medicine National Institute on Aging (NIA), National Institutes of Health (NIH), University of California, San Diego

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Effects of the interventions on changes in cognitive performance Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites. Approximately three years
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