Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)

Age-related Cognitive Decline Clinical Trial

— MEDEX-2  

Official title:

Resilience and Brain Health of Older Adults During the COVID-19 Pandemic (MEDEX-2)

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT05124132
• Other study ID #: 201810006
• Secondary ID: 1R01AG072694-01A
• Status: Enrolling by invitation
• Phase: N/A
• Start date: April 16, 2019
• Est. completion date: August 31, 2026

Study information

• Verified date: June 2024
• Source: Washington University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 468
• Est. completion date: August 31, 2026
• Est. primary completion date: August 31, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• Participated in the parent study, Protocol ID #201410093

Exclusion Criteria:

• Inability to safely continue classes or complete assessments, as per PI discretion

Related Conditions & MeSH terms

• Age-related Cognitive Decline
• Cognitive Dysfunction
• COVID-19

Intervention

Behavioral:
• Mindfulness-Based Stress Reduction
Mindfulness-Based Stress Reduction
• Exercise
Exercise
• Mindfulness-Based Stress Reduction + Exercise
Mindfulness-Based Stress Reduction + Exercise
• Health Education
Health Education

Locations

Country	Name	City	State
United States	Washington University School of Medicine	Saint Louis	Missouri

Sponsors (4)

Lead Sponsor	Collaborator
Washington University School of Medicine	National Institute on Aging (NIA), National Institutes of Health (NIH), University of California, San Diego

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effects of the interventions on changes in cognitive performance	Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites.	Approximately three years

External Links

•   Visit the Healthy Mind Lab for more information about the MEDEX study and our other areas of research. STL: http://healthymind.wustl.edu/medex UCSD: http://www.medexstudy.com/