Clinical Trials Logo
  1. Home
  2. Adverse Effect
  3. NCT04576663

Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia

Adverse Effect Clinical Trial

Official title:
Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia Undergoing Cesarean Section: a Randomized, Placebo-controlled Dose-finding Trial

Clinical Trial Summary

The purpose of this study is to investigate the suitable infusion dose of phenylephrine for prophylaxis against postspinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section.

Clinical Trial Description

Preeclampsia, which affects 5% to 7% of parturients, is a significant cause of maternal and neonatal morbidity and mortality. Because of constricted myometrial spiral arteries with exaggerated vasomotor responsiveness, though blood pressure in parturients with preeclampsia are apparently higher than healthy parturients, placental hypoperfusion is more common. Spinal anesthesia is still the preferred mode of anesthesia in parturients with preeclampsia for cesarean section. In preeclampsia parturients, spinal anesthesia improve intervillous blood flow (provided that hypotension is avoided) which contribute to increase placental perfusion. Even so, 17-26% parturients with preeclampsia experienced postspinal anesthesia hypotension due to the extensive sympathetic block that occurred with spinal anesthesia. Practical guidelines for obstetric anesthesia from the American Society of Anesthesiologists and an international consensus statement on the management of hypotension with vasopressors indicate either IV ephedrine or phenylephrine may be used to correct hypotension. But the suitable infusion dose of phenylephrine in parturients with preeclampsia is still unknown. The purpose of this study is to investigate the suitable infusion dose of phenylephrine for prophylaxis against post-spinal anesthesia hypotension in parturients with preeclampsia undergoing cesarean section. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04576663
Study type Interventional
Source General Hospital of Ningxia Medical University
Contact Xinli Ni, Dr.
Phone 86-951-674-3252
Email xinlini6@nyfy.com.cn
Status Not yet recruiting
Phase N/A
Start date October 1, 2023
Completion date September 21, 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT05035888 - Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension N/A
Completed NCT04028791 - Sickle Cell Trait and Exercise, Effect of Hot Environment N/A
Completed NCT04556357 - Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia N/A
Completed NCT04118322 - The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy N/A
Recruiting NCT03456544 - Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China
Completed NCT03723109 - Airway Management During TCI vs RSI Anesthesia Induction
Completed NCT03316417 - Study of Adverse Renal Effects of Immune Checkpoints Inhibitors
Completed NCT05712018 - Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine N/A
Completed NCT03006042 - Pharmacokinetics of BPV Following Bilateral US-guided TAP Block for C-section N/A
Completed NCT03011775 - Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease Phase 4
Completed NCT04556370 - Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia. N/A
Completed NCT03706755 - Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia Phase 4
Completed NCT02854787 - Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia Phase 4
Completed NCT02768168 - The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation N/A
Completed NCT04272567 - Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension N/A
Recruiting NCT05310331 - Donafenib for Recurrent Cervical Cancer Phase 2
Completed NCT05690334 - Different Crystalloid Coload Volumes on the 90% ED of Norepinephrine N/A
Not yet recruiting NCT06467045 - Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging
Completed NCT05475873 - Ondansetron for Postspinal Anesthesia Hypotension N/A
Recruiting NCT03220919 - Efficacy and Safety of Weight-Based Insulin Titration Regimen in Hospitalized Patients With Type 2 Diabetes N/A