Adverse Effect Clinical Trial
Official title:
Efficacy and Safety of Weight-Based Insulin Titration (WEB-IT) Regimen Compared With Glucose Level-based Regimen in Hospitalized Patients With Type 2 Diabetes: A Randomized Controlled Study
The investigators propose to use a weight-based regimen consisting of basal-bolus insulin and preprandial rapid-acting insulin and to test its efficacy and safety in controlling blood glucose in hospitalized patients with type 2 diabetes.
Patients with type 2 diabetes are randomly assigned by computer-generated block randomization
to receive either weight-based or glucose level-based titration regimen. All antidiabetic
drugs are discontinued on admission.
Starting dose:
Total daily insulin is 0.4U/kg. Half is given as glargine and the remainder as aspart which
is divided into three equal parts used for three pre-meal boluses.
Titration:
1. Weight-based insulin titration regimen:
Glargine titration: 0.1U/kg per day when fasting blood glucose (FBG) is over 8.0 mmol/L.
Aspart titration: total dose 0.1U/kg per day when next pre-meal blood glucose (BG) is
over 8.0 mmol/L, which is divided into three equal parts adding to three pre-meal
boluses.
2. Glucose level- based titration regimen:
Glargine titration: 4, 6, or 8 U when FBG is, respectively, within the following ranges:
8.0-8.9, 9.0-9.9, >10.0 mmol/L.
Aspart titration: 1, 3, 5, 7 or 8 U when next pre-meal BG is, respectively, within the
following ranges: 8.0-10.9, 11.0-13.9, 14.0-16.9, 17.0-19.9, > 20 mmol/L.
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