Adverse Effect Clinical Trial
Official title:
Adverse Renal Effects of Immune Checkpoints Inhibitors (Nivolumab, Pembrolizumab, Atezolizumab and Ipilimumab) in Clinical Practice: a Large Monocentric Prospective Study
Renal toxic events related to Immune Checkpoints Inhibitors therapy (Nivolumab,
Pembrolizumab, Atezolizumab and Ipilimumab) have been recently reported. These were
immune-allergic acute interstitial nephritis.
However, no systematic study has ever focused on renal adverse effects. The investigators
study here the evolution of renal function and the occurrence of nephrological events in a
large monocentric cohort of patients treated with Immune Checkpoints Inhibitors in the Centre
Hospitalier Lyon Sud. Nephrological parameters based on Serum Creatinine (SCr), estimate
Glomerular Filtration Rate (eGFR) and urinary sediment are monitored. The aim of the study is
to determine the incidence of renal events due to Immune Checkpoint Inhibitor treatment,
particularly Acute Kidney Injury, (AKI) and identify the clinical presentation, histological
description and risk factors.
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