| Eligibility |
Inclusion Criteria:
1. Able to comprehend and provide informed consent.
2. Males or females of 18 years of age or older
3. Have histologically-proven measurable, or evaluable advanced (systemically or locally
progressive), or metastatic solid tumors or the locally advanced disease is not
amenable to local therapy, who have failed, or are intolerant to standard therapy or
for whom no standard therapy is available. (For subjects with hepatocellular
carcinoma, the diagnosis needs to be supported by dynamic computed tomography
[CT]/magnetic resonance imaging, if pathological confirmation is not attainable) and
agree to provide tumor tissues (within 24 months) for genomic analysis (For subjects
who can provide the first NGS reports[The report was based on tumor tissues within 12
months prior to the subject's test] within 12 months prior to screening and has target
gene variation(s), it is recommended to provide their tumor tissue samples to the
central laboratory for testing, but the test results will not affect the
inclusion/exclusion evaluation of the subjects).
4. Harboring with below specific genetic alterations:
1. NFE2L2 mutations
2. STK11 mututions
3. RICTOR amplifications
4. Other genetic alterations maybe enrolled after discussion with Sponsor medical
monitor
5. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
6. A life expectancy longer than 3 months in the opinion of the Investigator.
7. Adequate hematologic functions, as defined by: absolute neutrophil counts = 1500/mm3;
a hemoglobin level = 9 g/dL; a platelet count = 100,000/mm3.
8. Adequate hepatic function defined by: a total bilirubin level = 1.5 × of upper limit
of normal (ULN); aspartate transaminase and alanine transaminase levels = 2.5 ×
ULN(AST and ALT =5 × ULN for subjects with liver metastasis).
9. Adequate renal function, as defined by the creatinine clearance = 50 mL/minute (as
calculated by the Cockcroft-Gault formula).
10. Females of child-bearing potential must have a negative pregnancy test upon entry into
this study and must be willing to use highly effective birth control upon enrollment,
during the Treatment Phase and for 180 days following the last dose of study drug. A
female is considered of child-bearing potential following menarche and until becoming
postmenopausal (no menstrual period for a minimum of 12 months) unless permanently
sterile (undergone a hysterectomy, bilateral salpingectomy, or bilateral
oophorectomy).
11. If male, must be surgically sterile or willing to use highly effective birth control
upon enrollment, during the Treatment Phase, and for 180 days following the last dose
of study drug.
12. Child-pugh score of A or B7 (for subjects with hepatocellular carcinoma only).
Exclusion Criteria:
1. Except for hearing loss and hair loss, all toxicity from previous antitumor therapy
was not recovered to=Grade 1 (according to National Cancer Institute-Common
Terminology Criteria Adverse Events [NCI-CTCAE], version 5.0).
2. Concurrent unstable or uncontrolled medical conditions, including:
1. Active systemic infections;
2. Poorly controlled hypertension (systolic blood pressure = 150 mmHg or diastolic
blood pressure = 100 mmHg), or poor compliance with antihypertensive agents;
3. Clinically significant arrhythmia, unstable angina pectoris, congestive heart
failure (Class II or IV of New York Heart Association) or acute myocardial
infarction;
4. Uncontrolled diabetes or poor compliance with hypoglycemic agents (as defined:
HbA1c >7%);
5. The presence of chronically unhealed wound or ulcers;
6. Other chronic diseases, which, in the opinion of the Investigator, could
compromise safety of the patient or the integrity of the study.
3. Poorly controlled pleural effusion or pericardial effusion (with clinical symptoms,
fluctuating or repeated drainage of effusion, oral diuretics, etc) existed in the
screening period. During the screening period, there are ascites that can be detected
on physical examination, or clinical symptoms caused by ascites, or special treatment
is required, such as repeated drainage, intraperitoneal drug perfusion, etc (the
presence of a small amount of ascites that can only be detected by imaging examination
may be considered for enrollment).
4. CNS metastases or involvement (except for the subjects with stable symptoms and no
recurrence within 2 years and be likely to obtain benefit from the study determined by
the investigator).
5. History of hepatic encephalopathy (only applicable to hepatocellular carcinoma
subjects).
6. Any concurrent malignancy other than basal cell carcinoma or carcinoma in situ of the
cervix. (Subjects with a previous malignancy but without evidence of disease for = 5
years can participate).
7. Females who are pregnant, lactating, or intend to become pregnant during their
participation in this study.
8. Current or prior use of immunosuppressive medication within 14 days before the first
dose. The following are exceptions to this criterion:
1. Intranasal, inhaled, topical steroids or local steroid injections (eg,
intra-articular injection), OR
2. systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
prednisone or equivalent, OR
3. steroids as premedication for hypersensitivity reactions (eg, CT scan
premedication).
9. Unable to swallow ATG-008 tables.
10. Major surgery was performed within 28 days prior to screening.
11. Had anti-tumor therapy (including radiotherapy and interventional therapy, etc),
systemic chemotherapy, hormone regulation therapy (such as tamoxifen), traditional
Chinese medicine therapy with anti-tumor indications, or clinical trial drugs, and
medical devices within 28 days prior to screening.
12. History of primary immunodeficiency or allogeneic transplantation.
13. History of human immunodeficiency virus (HIV) infection and/or acquired
immunodeficiency syndrome.
14. Active hepatitis B (HBsAg active), active hepatitis C virus (HCV) infection, defined
as having a positive HCV antibody test followed by a positive HCV RNA test at
Screening.
15. History of interstitial lung disease.
16. Receipt of live attenuated vaccines within 30 days prior to screening. Subjects, if
enrolled, should not receive live or live attenuated vaccines during the study.
17. Use/eating of drugs or food known to have potent CYP3A4 inhibitory effects within 2
weeks prior to screening, including but not limited to, atazanavir, clarithromycin,
Indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir,
telithromycin, vinegar oleandomycin, voriconazole, grapefruit and grapefruit juice.
18. Use of drugs known to have strong CYP3A4 induction within 2 weeks prior to screening,
including but not limited to carbamazepine, phenobarbital, phenytoin, rifabutin,
rifampicin, and St. John's wort.
19. Use of drugs as CYP3A4 substrates (with stenosis treatment index) within 2 weeks prior
to screening, including but not limited to dihydroergodemine, ergodemine, pimozide,
astimidazole, cisapride, and terfenadine.
20. Treatment with mTOR(TORC1and/orTORC2)inhibitor, included but not limited to sirolimus,
temsirolimus, everolimus, and other experimental or approved mTOR/PI3K/AKT inhibitors.
21. The subject is the investigator, sub-investigator, or anyone directly involved in the
conduct of the study.
22. The investigator considers that complications or other conditions of the subject may
affect the compliance with the protocol or make the subject unsuitable to participate
in the study.
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