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Clinical Trial Summary

This is a multicenter, open-label, first-time-in-human study with a standard 3+3 dose-escalation phase in participants with advanced solid tumors followed by an expansion phase in participants with advanced solid tumors. An exploration cohort has been added to determine the safety using every 4 weeks (Q4W) dosing.


Clinical Trial Description

A dose-escalation and dose-expansion study of MEDI4736 (a monoclonal antibody that targets programmed cell death ligand-1 (PD-L1)) will evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity (IM), and antitumor activity of MEDI4736 in adult participants with solid tumors. A dose exploration cohort will look at the safety profile of Q4W dosing of MEDI4736. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01693562
Study type Interventional
Source MedImmune LLC
Contact
Status Completed
Phase Phase 1/Phase 2
Start date September 5, 2012
Completion date February 28, 2020

See also
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