Clinical Trials Logo

Clinical Trial Summary

The purpose of the study is to evaluate the safety and tolerability of HLX60 combined with HLX10 in order to determine the maximum tolerated dose (MTD) and Recommended Phase 2 dose (RP2D) and to evaluate the preliminary efficacy for each combination regimen.


Clinical Trial Description

Accelerated titration and "3 + 3" dose escalation were used in this trial . various doses of HLX60(anti-GARP) combined with HLX10(anti-PD-1) by intravenous infusion. ;


Study Design


Related Conditions & MeSH terms

  • Advanced or Metastatic Solid Tumors
  • Neoplasms

NCT number NCT05483530
Study type Interventional
Source Shanghai Henlius Biotech
Contact
Status Active, not recruiting
Phase Phase 1
Start date December 14, 2022
Completion date August 2025

See also
  Status Clinical Trial Phase
Active, not recruiting NCT05017012 - A Study to Evaluate the Bioavailability of Pembrolizumab (MK-3475) Via Subcutaneous (SC) Injection of MK-3475A (Pembrolizumab Formulated With MK-5180) In Advanced Solid Tumors (MK-3475A-C18) Phase 1
Completed NCT02261532 - A Phase I Study of TAS-102 in Solid Tumors Phase 1
Completed NCT00748553 - A Phase I/II Clinical Trial of Vidaza With Abraxane in the Treatment of Patients With Advanced or Metastatic Solid Tumors and Breast Cancer Phase 1/Phase 2
Completed NCT03248843 - A Study of PD-L1 Antibody KN035 in Japanese Subjects With Locally Advanced or Metastatic Solid Tumors Phase 1
Recruiting NCT05572684 - A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants With Advanced Unresectable or Metastatic Solid Tumors Phase 1/Phase 2
Terminated NCT04003623 - Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208) Phase 2
Terminated NCT05496595 - DCBY02 as a Monotherapy in Patients With Advanced or Metastatic Solid Tumors Phase 1
Active, not recruiting NCT01928394 - A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors Phase 1/Phase 2
Terminated NCT01506934 - A Study Evaluating the Bioavailability of Two Formulations of Linifanib and Food Effect on Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors Phase 1
Completed NCT03730337 - Phase 1 Study of ONO-7475 With and Without ONO-4538 in Subjects Advanced or Metastatic Solid Tumors Phase 1
Recruiting NCT04586270 - A Study of TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer Phase 1
Recruiting NCT06248411 - A Clinical Study of KK2260 in Patients With Advanced or Metastatic Solid Tumors Phase 1
Not yet recruiting NCT06389526 - A Study of CHS-1000 in Participants With Advanced or Metastatic Solid Tumors Phase 1
Completed NCT03665285 - A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors Phase 1/Phase 2
Not yet recruiting NCT05957081 - Study to Assess the Safety, Tolerability, and Blood Concentration of PMC-309 Phase 1
Active, not recruiting NCT03316638 - A Study of a New Investigational Medicinal Product to Treat Patients With Advanced or Metastatic Solid Tumors Phase 1/Phase 2
Terminated NCT01355302 - E7050 in Combination With Cisplatin and Capecitabine Versus Cisplatin and Capecitabine Alone in Patients With Advanced or Metastatic Solid Tumors and Previously Untreated Gastric Cancer Phase 1/Phase 2
Completed NCT01014429 - Study of NMS-1286937 in Adult Patients With Advanced/Metastatic Solid Tumors Phase 1
Not yet recruiting NCT06074497 - A Phase 1, First-in-Human of KGX101 to Patients With Advanced or Metastatic Solid Tumors Phase 1
Recruiting NCT06448364 - A Study in Advanced/Metastatic Solid Tumors With the Study Medicine (PF-07329640) When Given Alone or In Combination Phase 1