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Adenomatous Polyps clinical trials

View clinical trials related to Adenomatous Polyps.

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NCT ID: NCT06342440 Recruiting - Colorectal Cancer Clinical Trials

Early Detection of Advanced Adenomas and Colorectal Cancer

AACRC
Start date: March 15, 2020
Phase:
Study type: Observational

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

NCT ID: NCT06305364 Recruiting - Clinical trials for Colorectal Neoplasms

Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

This is a prospective, multicenter, single-arm clinical investigation designed to evaluate the accuracy of the Gixam™ System in identifying subjects with colorectal adenomas compared to optical colonoscopy. Subjects arriving for a standard of care colonoscopy at the investigation site will be offered to participate in the study. Following an informed consent process, images of the subjects' tongue will be obtained with the Gixam™ System and a prediction score will be generated by the Gixam™ AI model. Subjects will thereafter proceed to their SOC colonoscopy, and the Gixam™ score will be compare with colonoscopy findings to evaluate its performance.

NCT ID: NCT06258434 Not yet recruiting - Colorectal Cancer Clinical Trials

Liquid Biopsy Based Multiomics Study for Colorectal Cancer Early Screening

COLO-LIMULOID
Start date: February 10, 2024
Phase:
Study type: Observational [Patient Registry]

The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed liquid biopsy based multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo) for detecting advanced neoplasia (including colorectal cancer and advanced adenomas) in high risk patients and patients with confirmed CRC, using colonoscopy as the reference method. The secondary objective is to compare the screening performance of the multiomics Colorectal Cancer (CRC) screening test with commercially available FIT (Fecal Immunochemical Test) assay in detecting advanced neoplasia.

NCT ID: NCT06220617 Recruiting - Colorectal Cancer Clinical Trials

Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)

Start date: January 11, 2024
Phase:
Study type: Observational

The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical performance externally.

NCT ID: NCT05988645 Recruiting - Colorectal Cancer Clinical Trials

Performance and Safety of MiWEndo-assisted Colonoscopy (MiWEndo II)

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

The study involves the planned use of a new microwave-based device during colonoscopy procedures in 50 patients to assess the performance and safety of its use for detection of colorectal polyps and lack of normal clinical practice modification. The device is a final design version, which has been previously tested in several preclinical studies (including phantom studies, an ex vivo study with human tissues, and an in vivo study with porcine model) and in a pilot study in humans (NCT05477836)

NCT ID: NCT05954949 Not yet recruiting - Adenomatous Polyps Clinical Trials

Detection of Ileoanal Pouch/Reservoir Adenomas

DARIAC
Start date: September 9, 2024
Phase:
Study type: Observational

The detection of adenomas is the basis for the follow-up of patients with familial adenomatous polyposis, after colectomy, with a remnant rectum or an ileal pouch. The optimal method for the adenomas detection is not defined yet. Despite the proven effectiveness of indigo-carmine in different indications dye chromoendoscopy is not used in a consensual way at the international level. The situation of the ileal pouch is specific as adenomas have a usually flat shape and are much more difficult to identify than in the situation of a remnant rectum, even in the situation of > 5 mm adenomas that should be resected. Our hypothesis is that indigo-carmine can improve adenomas detection, including > 5 mm adenomas, in patients with a an ileal pouch after colectomy improving the effectiveness of surveillance programs and potentially reducing the risk of cancer in this population.

NCT ID: NCT05875584 Completed - Colorectal Cancer Clinical Trials

Exploratory Study of a Novel Based rbcDNA Liquid Biopsy Technique for Colorectal Cancer Early Detection

Start date: May 18, 2023
Phase:
Study type: Observational

Exploration of a novel rbcDNA liquid biopsy technique for early detection of colorectal cancer is a promising development in the field of disease diagnosis and screening. This technique has the potential to establish an efficient and sensitive system for the early detection of colorectal cancer, which can provide a new perspective for individual health monitoring.

NCT ID: NCT05630794 Not yet recruiting - Clinical trials for Colorectal Carcinoma

Testing ONC201 to Prevent Colorectal Cancer

Start date: October 8, 2024
Phase: Phase 1
Study type: Interventional

This phase I trial tests the safety, side effects, and best dose of Akt/ERK Inhibitor ONC201 (ONC201) in preventing colorectal cancer in patients with familial adenomatous polyposis (FAP) or a history of multiple polyps. ONC201 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

NCT ID: NCT05477836 Completed - Colorectal Cancer Clinical Trials

Feasibility and Safety of MiWEndo-assisted Colonoscopy

MiWEndo1
Start date: October 18, 2022
Phase: N/A
Study type: Interventional

The study involves the planned use of a new microwave-based device during colonoscopy procedures in a small group of patients to assess the preliminary safety of its use and lack of normal clinical practice modification. The device is a final design version, which has been previously tested in several preclinical studies, including: phantom studies, an ex vivo study with human tissues, and an in vivo study with animal model (pig).

NCT ID: NCT05402124 Not yet recruiting - Colorectal Cancer Clinical Trials

The Colorectal Cancer Chemoprevention Acceleration and Improvement Platform (CRC-CHAMP) Study

Start date: July 2022
Phase: Phase 2
Study type: Interventional

The overall goal of this study is to develop a platform for both large-scale chemoprevention trials and real-world chemoprevention studies for colorectal cancer (CRC) prevention. The specific objectives of this proof of concept study are to: 1. Evaluate the feasibility of a real-world chemoprevention agent (CPA) intervention (3-months of daily low-dose acetylsalicylic (ASA)) in participants at increased risk for CRC (one or more high-risk adenomas removed during colonoscopy) based on participant uptake, adherence (days taking CPA), and adverse events; 2. Evaluate factors related to uptake and adherence of ASA using validated surveys and interviews.