Non-Operative Management and Early Response Assessment in Rectal Cancer — NOM-ERA  

Adenocarcinoma of the Lower Rectum Clinical Trial

Official title: Non-Operative Management and Early Response Assessment in Rectal Cancer

Status Active, not recruiting

Clinical Trial Summary

The investigators' data from a phase I study of short course radiation therapy followed by chemotherapy showed 74% complete clinical response (cCR). Given the promising response rate, the investigators are evaluating short course radiation therapy (SCRT) followed by chemotherapy in a multi-institution phase II trial to validate the cCR rate of this treatment paradigm. SCRT has not been prospectively evaluated in non-operative management for patients with non-metastatic rectal adenocarcinoma.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Adenocarcinoma
• Adenocarcinoma of the Lower Rectum
• Rectal Neoplasms

• NCT number: NCT03904043
• Study type: Interventional
• Source: Washington University School of Medicine
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 1, 2020
• Completion date: April 30, 2026