Lung Cancer Clinical Trial
Official title:
Tracking Genomic Cancer Evolution in Patients for Stage IB,II and IIIA Non-small Cell Lung Cancer After Radical Resection: The Tracking Molecular Evolution for NSCLC (T-MENC) Study
Tumor genomic clonal evolution assessed with liquid biopsy of stage IB,II and IIIA non-small cell lung cancer patients after getting radical resection. Plasma circulating tumor DNA (ctDNA) analysis detects molecule residual disease and predicts recurrence in patients. The concordance of the relative abundance of mutations in plasma ctDNA with cancer recurrence.
In the study, 200 of stage IB,II and IIIA non-small cell lung cancer patients obtained
radical resection will be recruited. All the patients will receive biopsy genotype assay and
ctDNA liquid biopsy. The abundance of mutations of ctDNA was tracked at 4 time points,
including:
1. st: 10 Days after patients received radical resection.
2. nd: When patients finished the chemotherapy or target drug delivery two cycles.
3. rd: 10 Days after patients finished the chemotherapy or target drug delivery four
cycles.
4. th: When tumor recrudescence / 2 years after radical resection.
Tumor genomic clonal evolution was assessed by analyzing the relative abundance of mutations
in plasma circulating tumor DNA (ctDNA).
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