Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute

Status Completed

Clinical Trial Summary

Currently, early reperfusion is considered as the most effective therapy for the treatment of acute ischemic stroke (AIS). Over the past 20 years, intravenous tissue plasminogen activator (IV tPA) has been demonstrated to be the only effective therapy for AIS. More recently, several large randomized clinical trials have concluded the superiority of endovascular mechanical thrombectomy for AIS. Furthermore, with the development of materials and techniques, the occluded artery can be recanalized with high percentage (60%-90%), and the rate of recanalization is still being improved. A great number of AIS patients are now eligible for revascularization therapy and there should be a good prognosis of AIS after recanalizing the occluded artery using mechanical thrombectomy. However, things are never as simple as wished to be. The rate of patients with functional independence is less than 50% and over 15% patients died at 3 months post thrombectomy. The discrepancy between the functional outcome and recanalization rates encourage researchers to explore strategies that further improving the functional outcome of AIS patients.

Remote ischemic conditioning has been demonstrated to reduce cerebral infarct size in mouse model of focal cerebral ischemia. And clinical researches demonstrated the protective effects of remote ischemic conditioning in AIS patient treated with IV tPA,. However, whether remote ischemic conditioning is safe and effective in protecting patients with large-vessel ischemic stroke and undergoing endovascular treatment is still unknown.

Clinical Trial Description

In the present study, the investigators will assess the safety and feasibility of remote ischemic condition paired with endovascular treatment for AIS. A single arm of AIS patients treated with endovascular therapy will be recruited, and remote ischemic conditioning will be applied prior to reperfusion therapy and in combination with post reperfusion therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03210051
Study type	Interventional
Source	Capital Medical University
Contact
Status	Completed
Phase	Phase 1
Start date	July 7, 2017
Completion date	December 20, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03281590` - Stroke and Cerebrovascular Diseases Registry
Enrolling by invitation	`NCT06074081` - Comparison of 4-weeks of Motor Relearning Program and Mirror Therapy in Improving Upper Limb Motor Function in Stroke Patients.	N/A
Terminated	`NCT04039178` - Efficacy of EMF BCI Based Device on Acute Stroke	N/A
Completed	`NCT04521634` - Glycaemic Variability in Acute Stroke
Completed	`NCT03477188` - The Effects of Somatosensory and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke.	N/A
Recruiting	`NCT05065216` - Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)	Phase 2/Phase 3
Recruiting	`NCT02677415` - Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment	N/A
Recruiting	`NCT01541163` - Heart and Ischemic STrOke Relationship studY	N/A
Completed	`NCT01210729` - Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke	Phase 2
Recruiting	`NCT00785343` - Study of Robot-assisted Arm Therapy for Acute Stroke Patients	Phase 1
Completed	`NCT04779710` - How Does Dysphagia Assessment in Acute Stroke Affect Pneumonia?
Active, not recruiting	`NCT03635749` - Intensive Medical Therapy for High-risk Intracranial or Extracranial Atherosclerosis	Phase 3
Recruiting	`NCT06149754` - BraiN20® Monitoring in Acute Stroke Undergoing Thrombectomy
Recruiting	`NCT04491695` - Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke	Phase 2/Phase 3
Recruiting	`NCT04283760` - Investigation of the Reliability and Validity of the Movement Imagination Questionnaire - Revised Second in Acute Stroke Patients
Recruiting	`NCT05454397` - A Study on the Status of Nutritional Risk Screening and Nutritional Therapy in Neurology Hospitalized Stroke Patients
Completed	`NCT04488692` - Early Functional Training in Acute Stroke Inpatient Ward	N/A
Recruiting	`NCT04214522` - Reliability and Validity of the Kinesthetic and Visual Imagery Questionnaire in Acute Stroke Patients
Not yet recruiting	`NCT04157231` - Essential Acute Stroke Care in Low Resource Settings: a Pilot studY	N/A
Recruiting	`NCT05469438` - IMAS Optimization and Applicability in an Acute Stroke Setting.

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Remote Ischemic Conditioning Paired With Endovascular Treatment for Acute Ischemic Stroke (REVISE-1)

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms