Acute Stroke Clinical Trial
Official title:
A Proof-of-Concept Study Assessing the Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
Ischemic stroke, which is due to the occlusion of a cerebral blood vessel, comprises nearly
80-90% of all strokes. Currently, reperfusion of the salvageable tissue via thrombolytic drug
or endovascular treatment is the most effective strategy to reduce brain damage. However,
after recanalizing the occluded vessels, subsequent reperfusion injury is inevitable. It may
not only weaken the therapeutic effects of timely reperfusion but also impede patients'
recovery. Moreover, thousands of neuroprotective drugs effective in experimental models have
been proved to be unsuccessful in clinical trials. Therefore, effective strategies are
urgently needed to prevent and treat cerebral reperfusion injury and further improve the
prognosis of acute ischemic stroke.
Researchers applied remote ischemic conditioning to mouse model of focal cerebral reperfusion
injury and found that it could reduce cerebral infarct size. And clinical researches
demonstrated that remote ischemic conditioning was an effective strategy to improve cerebral
perfusion and prevent recurrent stroke in patients with ischemic stroke. However, whether
remote ischemic conditioning is safe and effective in protecting patients with large-vessel
ischemic stroke and undergoing endovascular treatment is still unclear. The investigators'
hypothesis is that RIC is a safe and effective strategy to reduce brain injuries in stroke
patients undergoing endovascular treatment.
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