Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment

Acute Stroke Clinical Trial

— CANVAS  

Official title:

Impact of General vs Local Anesthesia on Neurological Function in Patients With Acute Ischemic Stroke Undergoing Endovascular Treatment

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02677415
• Other study ID #: QML20150508
• Status: Recruiting
• Phase: N/A
• Start date: September 2016
• Est. completion date: December 2022

Study information

• Verified date: September 2021
• Source: Beijing Tiantan Hospital
• Contact: Ruquan Han, M.D., Ph.D.
• Phone: 8610-67096660
• Email: ruquan.han[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 640
• Est. completion date: December 2022
• Est. primary completion date: December 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with AIS scheduled to receive emergency endovascular treatment, older than 18; the onset time is within 12 hours.

Exclusion Criteria:

• Radiological ambiguity concerning infarction and vessel occlusion.

• Additional intracerebral hemorrhage.

• Posterior circulation infraction.

• Coma on admission (Glasgow coma score less than 8).

• NIHSS less than 10 or more than 35.

• Severe agitation or seizures on admission.

• Obvious loss of airway protective reflexes and/or vomiting on admission.

• Being intubated before treatment on admission.

• Known allergy to anesthetic or analgesic.

Related Conditions & MeSH terms

• Acute Stroke
• Stroke

Intervention

Other:
• Intravenous anesthetics

• local anesthesia

• Controlled ventilation

• Spontaneous breathing

Locations

Country	Name	City	State
China	Beijing TianTan Hospital	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Tiantan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	modified Rankin score		post-procedural 30 days