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Treatment of ARDS With Sivelestat Sodium — TOAWSS  

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Efficacy of Sivelestat Sodium in the Treatment of ARDS With SIRS, a Multicenter Double-blind Randomized Controlled Clinical Trial

Clinical Trial Summary

Neutrophil elastase (NE) released by neutrophils play an important role in inflammatory cascade and lung tissue injury of ARDS.Inhibition of NE is expected to prevent the pathophysiological process of ARDS and alleviate lung injury. Siverestat sodium is a specific inhibitor of NE, which has been proved by basic and observational clinical studies to be effective in alleviating lung injury of ARDS, but there is a lack of prospective multi-center randomized controlled clinical trials.Therefore, this study was intended to evaluate the efficacy of sivelestat sodium in the treatment of ARDS patients with SIRS in a multicenter randomized controlled clinical trial

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04909697
Study type Interventional
Source Sichuan Provincial People's Hospital
Contact Hongli He, Ph.D.
Phone +86-28-87393633
Email hhl0408@163.com
Status Recruiting
Phase Phase 4
Start date April 18, 2022
Completion date July 30, 2024
View Details
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