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Macrophage Programing in Acute Lung Injury

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Macrophage Programing in Acute Lung Injury

Clinical Trial Summary

The histologic hallmarks of lung inflammation and in the extreme, acute respiratory distress syndrome (ARDS), include intense accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and endothelial cells, loss of epithelial-capillary integrity and accumulation of edema fluid in the interstitium and airspaces. Accordingly, for alveolar repair to occur inflammation must be halted, debris and inflammatory cells removed, injured tissue cells replaced, and capillary barrier function re-established. Macrophages are key players in all of these. Here the investigators hypothesize that resident alveolar macrophages and recruited macrophages serve completely different functions, acting independently (i.e. division of labor) yet cooperatively (synergism).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Acute Lung Injury
  • Acute Respiratory Distress Syndrome
  • Lung Injury
  • Respiratory Distress Syndrome, Adult
  • Respiratory Distress Syndrome, Newborn
Clinical Trial Details
NCT number NCT03844893
Study type Observational
Source National Jewish Health
Contact Christine Griesmer, MPH
Phone 303-398-1325
Email griesmerc@njhealth.org
Status Not yet recruiting
Phase
Start date October 2019
Completion date March 2023
View Details
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