Comparison of Postoperative Outcomes Between Surgeries Anaesthetized With Propofol and Inhalational Anaesthetics

Acute Pain Clinical Trial

Official title:

Comparison of Postoperative Outcomes Between Surgeries Anaesthetized With Propofol and Inhalational Anaesthetics With Regression Controls for Confounders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03875872
• Other study ID #: UW19-182
• Status: Completed
• Start date: February 11, 2019
• Est. completion date: August 12, 2019

Study information

• Verified date: May 2023
• Source: The University of Hong Kong
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Propofol used as anaesthesia in surgery had shown small postoperative analgesic benefits over inhalational anaesthetics in some meta-analyses. It was also associated with reduced risk of postoperative nausea and vomiting. Small sample of studies together with high heterogeneity prevented some meta-analyses to confirm propofol's effect for postoperative morphine consumption and other outcomes. Acute Pain Service data bank can provide an alternative way of evaluating postoperative outcomes of propofol anaesthetics through supplying a very large sample size in a more homogeneous setting. Retrospective study comparing propofol and inhalational anaesthetics on postoperative pain matched on patients' demographic and clinical data had been done for liver surgery. Propofol's benefits for postoperative pain and morphine consumption was confirmed but not for adverse effects.

This study plans to analyze the postoperative outcome data from an Acute Pain Service data bank in years 2015-17 to compare the anaesthetics of propofol and inhalational anaesthetics. Comprehensive regression adjustment for confounders are performed using all available patients' demographic, clinical and anaesthetic data. All major surgery types are included. Results will provide postoperative outcome differences between propofol and inhalational anaesthetics for all surgeries and for specific type of surgeries. The large sample bank will provide higher probability for detecting outcome difference between the anaesthetics for all the major surgical types.

Description:

Objective: To compare the postoperative outcomes between surgeries anaesthetized with propofol and inhalational anaesthetics in the Acute Pain Service records of Queen Mary Hospital for years 2015-17

Methods:

Retrospective

Data collection

1. Demographic data;

2. Type of surgery;

3. Type of anaesthetic techniques;

4. Postoperative NRS pain scores (Rest and Moving) for Postop Days 1, 2 & 3;

5. Accumulated amount of patient controlled analgesia (PCA) used in Postop Days 1, 2 & 3;

6. Postoperative incidence of nausea, vomitting, dizziness and pruritus.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 3922
• Est. completion date: August 12, 2019
• Est. primary completion date: August 12, 2019
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Postoperative outcomes from Acute Pain Service data bank between Jan 2015 and Dec 2017 in Queen Mary Hospital would be retrieved;

2. Surgeries with general anaesthesia by either propofol or inhalational anaesthetics.

Exclusion Criteria:

1. Essential data missed;

2. Surgical types with small sample size below 30 for the data collection period.

Related Conditions & MeSH terms

• Acute Pain

Intervention

Drug:
• Propofol
Patients who had surgeries and were anaesthetized with propofol at Queen Mary Hospital, Hong Kong from Jan 2015 to Dec 2017
• inhalation anaesthetics
Patients who had surgeries and were anaesthetized via inhalation at Queen Mary Hospital, Hong Kong from Jan 2015 to Dec 2017

Locations

Country	Name	City	State
Hong Kong	The University of Hong Kong	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
The University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

References & Publications (4)

Chan AC, Qiu Q, Choi SW, Wong SS, Chan AC, Irwin MG, Cheung CW. Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study. PLoS One. 2016 Feb 22;11(2):e0149753. doi: 10.1371/journal.pone.0149753. eCollection 2016. — View Citation

Kumar G, Stendall C, Mistry R, Gurusamy K, Walker D. A comparison of total intravenous anaesthesia using propofol with sevoflurane or desflurane in ambulatory surgery: systematic review and meta-analysis. Anaesthesia. 2014 Oct;69(10):1138-50. doi: 10.1111/anae.12713. Epub 2014 May 22. — View Citation

Peng K, Liu HY, Wu SR, Liu H, Zhang ZC, Ji FH. Does Propofol Anesthesia Lead to Less Postoperative Pain Compared With Inhalational Anesthesia?: A Systematic Review and Meta-analysis. Anesth Analg. 2016 Oct;123(4):846-58. doi: 10.1213/ANE.0000000000001504. — View Citation

Qiu Q, Choi SW, Wong SS, Irwin MG, Cheung CW. Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes - a systematic review and meta-analysis. Anaesthesia. 2016 Oct;71(10):1222-33. doi: 10.1111/anae.13578. Epub 2016 Aug 10. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pain score	NRS (0-10) for both rest and moving	up to postoperative day 3
Secondary	analgesic consumption	amount of accumulated patient controlled analgesia (PCA) of morphine use	up to postoperative day 3
Secondary	Amount of patients with adverse events in post-operation	nausea and vomit, dizziness and pruritus	up to postoperative day 3