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Comparison of Postoperative Outcomes Between Surgeries Anaesthetized With Propofol and Inhalational Anaesthetics

Acute Pain Clinical Trial

Official title:
Comparison of Postoperative Outcomes Between Surgeries Anaesthetized With Propofol and Inhalational Anaesthetics With Regression Controls for Confounders

Clinical Trial Summary

Propofol used as anaesthesia in surgery had shown small postoperative analgesic benefits over inhalational anaesthetics in some meta-analyses. It was also associated with reduced risk of postoperative nausea and vomiting. Small sample of studies together with high heterogeneity prevented some meta-analyses to confirm propofol's effect for postoperative morphine consumption and other outcomes. Acute Pain Service data bank can provide an alternative way of evaluating postoperative outcomes of propofol anaesthetics through supplying a very large sample size in a more homogeneous setting. Retrospective study comparing propofol and inhalational anaesthetics on postoperative pain matched on patients' demographic and clinical data had been done for liver surgery. Propofol's benefits for postoperative pain and morphine consumption was confirmed but not for adverse effects. This study plans to analyze the postoperative outcome data from an Acute Pain Service data bank in years 2015-17 to compare the anaesthetics of propofol and inhalational anaesthetics. Comprehensive regression adjustment for confounders are performed using all available patients' demographic, clinical and anaesthetic data. All major surgery types are included. Results will provide postoperative outcome differences between propofol and inhalational anaesthetics for all surgeries and for specific type of surgeries. The large sample bank will provide higher probability for detecting outcome difference between the anaesthetics for all the major surgical types.

Clinical Trial Description

Objective: To compare the postoperative outcomes between surgeries anaesthetized with propofol and inhalational anaesthetics in the Acute Pain Service records of Queen Mary Hospital for years 2015-17 Methods: Retrospective Data collection 1. Demographic data; 2. Type of surgery; 3. Type of anaesthetic techniques; 4. Postoperative NRS pain scores (Rest and Moving) for Postop Days 1, 2 & 3; 5. Accumulated amount of patient controlled analgesia (PCA) used in Postop Days 1, 2 & 3; 6. Postoperative incidence of nausea, vomitting, dizziness and pruritus. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03875872
Study type Observational
Source The University of Hong Kong
Contact
Status Completed
Phase
Start date February 11, 2019
Completion date August 12, 2019
View Details
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