Association of Air Quality and Myocardial Infarction

Acute Myocardial Infarction Clinical Trial

Official title:

Association of Air Quality and Myocardial Infarction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02880436
• Other study ID #: 28-292ex15/16
• Status: Completed
• Phase: N/A
• First received: August 16, 2016
• Last updated: August 24, 2017
• Start date: January 2007
• Est. completion date: June 30, 2017

Study information

• Verified date: August 2017
• Source: Medical University of Graz
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described.

Particulate matter, especially with small particle size (<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation.

With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous.

Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis.

The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions

Description:

The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12000
• Est. completion date: June 30, 2017
• Est. primary completion date: June 30, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• myocardial infarction being confirmed or treated in the cathlab

Exclusion Criteria:

Related Conditions & MeSH terms

• Acute Myocardial Infarction
• Infarction
• Myocardial Infarction

Intervention

Other:
• air pollution
impact of various pollution agents above threshold and their correlation with acute myocardial infarctions are analyzed

Locations

Country	Name	City	State
Austria	Medical University of Graz	Graz

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Graz

Country where clinical trial is conducted

Austria, 

References & Publications (4)

Barnett AG, Williams GM, Schwartz J, Best TL, Neller AH, Petroeschevsky AL, Simpson RW. The effects of air pollution on hospitalizations for cardiovascular disease in elderly people in Australian and New Zealand cities. Environ Health Perspect. 2006 Jul;114(7):1018-23. — View Citation

Bhaskaran K, Hajat S, Haines A, Herrett E, Wilkinson P, Smeeth L. Effects of air pollution on the incidence of myocardial infarction. Heart. 2009 Nov;95(21):1746-59. doi: 10.1136/hrt.2009.175018. Epub 2009 Jul 26. Review. — View Citation

Ruidavets JB, Cournot M, Cassadou S, Giroux M, Meybeck M, Ferrières J. Ozone air pollution is associated with acute myocardial infarction. Circulation. 2005 Feb 8;111(5):563-9. — View Citation

Sen T, Astarcioglu MA, Asarcikli LD, Kilit C, Kafes H, Parspur A, Yaymaci M, Pinar M, Tüfekcioglu O, Amasyali B. The effects of air pollution and weather conditions on the incidence of acute myocardial infarction. Am J Emerg Med. 2016 Mar;34(3):449-54. doi: 10.1016/j.ajem.2015.11.068. Epub 2015 Dec 4. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	myocardial infarction	the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of air polluting substances	1 day