Acute Myocardial Infarction Clinical Trial
Official title:
Evaluation of Neointimal Coverage of Everolimus-Eluting Stent and Bare-metal Stent After Implantation in STEMI Patients by Optical Coherence Tomography
Primary percutaneous coronary intervention (PCI) represents the preferred reperfusion
strategy for patients with ST-segment elevation myocardial infarction (STEMI), since it is
more effective than thrombolytic regimens in reducing adverse events, including death.
Drug-eluting stents (DES) are currently being widely used in patients with STEMI. The
effectiveness of DES to reduce restenosis and the need for revascularization compared with
bare-metal stents (BMS) has been documented in randomized controlled trials. The
first-generation DESs implanted in STEMI have been associated with delayed healing and
incomplete strut coverage. Therefore, in patients with implanted DES, longer duration of
dual antiplatelet therapy is needed. The second-generation DESs (ZES and EES) have been
improved the drug and polymer, which have been proved to improve neointima healing compared
with the first generation DESs.
However, the difference of strut coverage between EES and BMS implanted in STEMI patients is
unknown. In this study, we assess the neointimal coverage at 3-month and 12-month follow-up
in EES and BMS implanted in patients with STEMI by optical coherence tomography.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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