Acute Myocardial Infarction Clinical Trial
Official title:
Effectiveness of Intracoronary Injection of Eptifibatide as Adjunctive Antiplatelet Therapy in Primary Coronary Intervention in Patients With ST Segment Elevation Acute Myocardial Infarction.
The achievement of high local concentration of Eptifibatide, a GP 2b3a inhibitor,via direct
intracoronary injection, promotes (in vitro) clot disaggregation. It remains unclear if it
is of superior benefit than the routine intravenous administration of these agents.
In patients presenting with acute myocardial infarction, and undergoing primary coronary
intervention, intracoronary administration of Eptifibatide may increase local drug
concentration by several orders of magnitude and promote clot disaggregation with a minimal
increase in systemic drug concentration, and in that way enhancing myocardial perfusion and
survival.
Patients will be randomized, prospectively, single blinded into one of two
arms:1)intravenous administration of Eptifibatide and 2) intracoronary administration. The
primary end-point will be the angiographic achievement of TIMI 3 flow at the infarct related
artery and TIMI myocardial perfusion grade (blush) and the electrocardiographic surrogate of
myocardial perfusion the ST segment resolution.
The secondary end-points will be the occurrence of bleeding or hemorrhagic complication
according to TIMI classification and the LVEF at one month compared with baseline
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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