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NCT02693912 Clinical Trial

Changes in Alveolar Macrophage Function During Acute Lung Injury

Acute Lung Injury Clinical Trial

Official title:
Changes in Alveolar Macrophage Function During Acute Lung Injury

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT02693912
Other study ID # wch-150718
Secondary ID
Status Not yet recruiting
Phase N/A
First received February 11, 2016
Last updated February 26, 2016
Start date September 2016
Est. completion date August 2018

Study information
Verified date February 2016
Source West China Hospital
Contact Chunling Jiang
Email jiang_chunling@yahoo.com
Is FDA regulated No
Health authority China: Ethics Committee
Study type Observational

Clinical Trial Summary

In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.

Description:

Alveolar macrophages are tissue-resident or recruited cells with key functions in recognition of pathogens, initiation of host defensive ang protective inflammation,and in clearance of pathogens from the airways. However, macrophages are also responsible for efficient clearance of apoptotic neutrophils, termed efferocytosis, which is a prerequisite for the timely resolution of inflammation. In this study, the investigators aim to observe the change in alveolar macrophage function during acute lung injury.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 25
Est. completion date August 2018
Est. primary completion date December 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients in ICU with diagnosed ALI under mechanical ventilation

Exclusion Criteria:

- Patients with cardiac dysfunction, using steroid drugs or other drugs can that affect efferocytosis

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Procedure:
• Bronchoscopy
Bronchoscopy will be implemented under sedation in both groups.

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
West China Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary alveolar macrophages (AMs) phagocytic index AMs will be collected and cultured in vitro. Apoptotic neutrophils will then be cocultured with AMs for 1 hour. To measure phagocytosis of apoptotic neutrophils, AMs were further processed and phagocytosed apoptotic neutrophils were detected by confocal fluorescence microscopy as described below under Cell staining and confocal microscopy. The phagocytic index was calculated according to the following formula: phagocytic index = (total number of engulfed cells/total number of counted macrophages) × (number of macrophages containing engulfed cells/total number of counted macrophages) × 100. 7 days after admission No
Secondary 30 days mortality 30 days after admission No
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