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Acute Lung Injury After Allogeneic Transplantation - Diagnosis and Early Treatment

Acute Lung Injury Clinical Trial

Official title:
A Randomized Clinical Trial on the Use of Early Intermittent Non-Invasive Ventilation in Patients Suffering From Acute Lung Injury After Allogeneic Transplantation

Clinical Trial Summary

Acute lung injury (ALI) is an early complication after allogeneic transplantation causing significant mortality and morbidity. Little is known on early markers and treatment of this complication. Recent data (Hilbert et al.) suggested a beneficial effect of Non-Invasive-Ventilation in ALI-patients immunosuppressed because a many different reasons including stem-cell transplantation.

The investigators study is designed to evaluate early markers of ALI after allogeneic transplantation. In case ALI is documented patients are randomized to either conventional therapy (oxygen-support) or conventional therapy plus intermittent Non-Invasive Ventilation. The hypothesis is that Non-Invasive Ventilation improves outcome of ALI after allogeneic transplantation.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Masking: Open Label

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00852605
Study type Interventional
Source Technische Universität Dresden
Contact
Status Completed
Phase Phase 1/Phase 2
Start date December 2001
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