Effect of Variable PSV in Acute Lung Injury: Part I and Part II

Acute Lung Injury (ALI) Clinical Trial

Official title: Physiological Research on Variable Pressure Support Ventilation in Patients With Acute Acute Lung Injury: Part I and Part II

Status Completed

Clinical Trial Summary

Noisy Pressure Support Ventilation (noisy-PSV) would lead to improved lung function, while preserving respiratory muscle unloading. Basically, noisy PSV differs from other assisted mechanical ventilation modes that may also increase the variability of the respiratory pattern (e.g. proportional assist ventilation) by the fact that the variability does not depend on changes in the patient's inspiratory efforts.

The aim of this study is to evaluate the optimal variability for noisy PSV in patients with ALI based on its effects on respiratory mechanics, breathing comfort, gas exchange, and hemodynamics. The investigators hypothesize that noise in pressure support leads to variations in VT that are able to improve lung function and that physiologic variables respond differently to the degree of variability in pressure support

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Acute Distress Respiratory Syndrome (ARDS)
• Acute Lung Injury
• Acute Lung Injury (ALI)
• Lung Injury
• Respiratory Distress Syndrome, Adult
• Respiratory Distress Syndrome, Newborn
• Wounds and Injuries

• NCT number: NCT01683669
• Study type: Interventional
• Source: University of Genova
• Status: Completed
• Phase: N/A
• Start date: August 2012
• Completion date: December 2016