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Hyperosmolality and Acute Kidney Injury After Cardiac Surgery

Acute Kidney Injury Clinical Trial

Official title:
Hyperosmolar Priming Solution for Cardiopulmonary Bypass May Increase the Risk for Postoperative Acute Kidney Injury: Results From Double-blinded Randomised Controlled Trial

Clinical Trial Summary

The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.

Clinical Trial Description

Two-hundred cardiac surgical patients were randomised into two groups based on the osmolality level of the prime solution used for cardiopulmonary bypass. The high osmolality group (966 mOsm) received a prime solution containing Ringer-Acetate 1000 ml + Mannitol 400 ml (60 g) + Sodium-Chloride 40 ml (160 mmol) and Heparin 2 ml (10 000 IU), while the reference group with normal osmolality (388 mOsm) received a prime solution containing Ringer-Acetate 1400 ml and Heparin 2 ml (10 000 IU). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05914896
Study type Interventional
Source Umeå University
Contact
Status Completed
Phase N/A
Start date April 24, 2019
Completion date June 24, 2020
View Details
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