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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05242705
Other study ID # SHSAS
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date March 1, 2022
Est. completion date December 31, 2024

Study information

Verified date February 2022
Source Assiut University
Contact Heba Ahmed Abd El Hafeez, Professor
Phone +201006268407
Email dr_heba.ahmed@yahoo.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute Kidney Injury (AKI) is defined as an absolute increase in serum creatinine ≥0.3 mg/dl (≥26.4 μmol/l), a percentage increase in serum creatinine ≥50% (1.5-fold from baseline), or a reduction in urine output (documented oliguria < 0.5 ml/kg/hour for > 6 hours) S.creatinine which is considered the gold standard currently for diagnosis of AKI remains unchanged until 50% of kidney function falls down. It is affected by non-specific factors like diet, age, dehydration, muscle mass, gender, and drugs. There were evidences of the association between AKI and acute coronary syndrome (ACS); First, AKI detection may be missed by cardiologists. Physicians tend to disregard mild or transient serum creatinine elevation during hospital stay for ACS, and they often attribute small serum creatinine increases to laboratory variations.


Description:

Cystatin C (CysC), a cystatin protease inhibitor, is less affected by non-specific factors. When glomerular filtration rate (GFR) decreases, CysC begins to increase. CysC was recommended to be measured in addition to creatinine in GFR estimation. Cysteine-rich protein 61 (Cyr61) is a cysteine-rich secretory protein that promotes cell proliferation, adhesion, chemotaxis, embryonic development and neovascularization . Previous studies have detected low expression level of Cyr61 in normal adult kidney and high expression of Cyr61 in ischemic rats and mice kidney, which suggests that Cyr61 may be a potential biomarker for diagnosis of AKI . CYR61 might possibly identify patients with more severe kidney injury, which would be very beneficial for early treatment of AKI after


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 45
Est. completion date December 31, 2024
Est. primary completion date December 31, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 90 Years
Eligibility Inclusion Criteria: 1. Age = 18 years. 2. Informed consent 3. Patient with absolute increase in serum creatinine =0.3 mg/dl (=26.4 µmol/l) or with percentage increase in serum creatinine =50% (1.5-fold from baseline) 4. Patient with reduction in urine output (documented oliguria < 0.5 ml/kg/hour for > 6 hours) 5. Patient with typical chest pain, ECG changes, Echocardiogram positive finding Exclusion Criteria: 1. History of nephrectomy 2. patient with renal transplantation 3. patient with renal replacement therapy initiated before admission 4. patient with chronic kidney disease 5. patient on regular haemodialysis 6. patient known to be diabetic

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
Serum Cysteine Rich Protein 61
collection of serum samples for chemical analysis

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Assiut University

References & Publications (4)

Marenzi G, Cosentino N, Bartorelli AL. Acute kidney injury in patients with acute coronary syndromes. Heart. 2015 Nov;101(22):1778-85. doi: 10.1136/heartjnl-2015-307773. Epub 2015 Aug 4. Review. — View Citation

Mosa OF, Skitek M, Kalisnik JM, Jerin A. Evaluation of serum cysteine-rich protein 61 and cystatin C levels for assessment of acute kidney injury after cardiac surgery. Ren Fail. 2016 Jun;38(5):699-705. doi: 10.3109/0886022X.2016.1157747. Epub 2016 Mar 16. — View Citation

Shlipak MG, Mattes MD, Peralta CA. Update on cystatin C: incorporation into clinical practice. Am J Kidney Dis. 2013 Sep;62(3):595-603. doi: 10.1053/j.ajkd.2013.03.027. Epub 2013 May 20. Review. — View Citation

Zhang Z, Lu B, Sheng X, Jin N. Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis. Am J Kidney Dis. 2011 Sep;58(3):356-65. doi: 10.1053/j.ajkd.2011.02.389. Epub 2011 May 20. Review. Erratum in: Am J Kidney Dis. 2012 Apr;59(4):590-2. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Early detection of acute kidney injury in patient with acute coronary syndromes after cardiac interventional surgeries as primary percutaneous coronary intervention (PCI) Early detection of acute kidney injury in patient with acute coronary syndromes after cardiac interventional surgeries as primary percutaneous coronary intervention (PCI) 3 years
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