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Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study — NEB-HF  

Acute Kidney Injury Clinical Trial

Official title:
Furosemide With Early Sequential Nephron Blockade Versus Furosemide Alone in Acute Heart Failure Patients With Furosemide-guided Diuretic Resistance: A Double-blinded, Randomized, Placebo-controlled Study

Clinical Trial Summary

This study aims to demonstrate the efficacy of sequential nephron blockade by adding hydrochlorothiazide or spironolactone on intravenous furosemide compared to intravenous furosemide alone in the treatments of volume overload in patients with acute heart failure who have diuretic resistance from furosemide stress test.

Clinical Trial Description

This study is a randomised, double-blinded, double-dummy, placebo-controlled study to demonstrate the efficacy of oral hydrochlorothiazide or spironolactone in combination with intravenous furosemide compared to intravenous furosemide in combination with placebo. Dosage of intravenous furosemide will be adjusted according to pre-defined protocol. The primary outcome is urine volume during 72 hours after randomisation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04465123
Study type Interventional
Source Chiang Mai University
Contact Kajohnsak Noppakun, MD
Phone +66815953465
Email kajohnsak.noppakun@cmu.ac.th
Status Recruiting
Phase Phase 3
Start date August 13, 2020
Completion date December 31, 2022
View Details
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