Acute Kidney Injury Clinical Trial
Official title:
Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock? HEMOCHECK
Septic shock is one of the leading causes of death in patients admitted to the intensive care
unit (ICU). Acute kidney injury (AKI) occurs in almost 50% of septic patients and is
associated with significant mortality. Progression to the last stage (KDIGO stage 3) of AKI
is an important step in the disease, as it usually requires initiation of RRT. Renal
biomarkers are unable to accurately identify those patients who will progress to severe AKI
(KDIGO 3). However, identification of patients at risk of progression to severe AKI could
help the clinician to initiate optimal therapy including RRT. A new urine test, the
Nephrocheck⢠corresponding to the product of the urinary concentrations of 2 markers of renal
tubule injury (TIMP2 and IGFBP7) has been validated. The Investigator have already performed
two previous studies including septic shock patients (AKICHECK and BIOOCHECK). those previous
datas will be reanalysed to examine whether the new urinary biomarkers TIMP2 and IGFBP7 can
predict progression within 24 hours and 72 hours from mild and moderate (KDIGO 1 or 2) to
severe AKI (KDIGO 3) in patients with septic shock.
-All the datas required will be collected from two previous studies (AKICHECK and BIOCHECK)
performed in 3 centers: Amiens medical ICU, Melun medico surgical ICU and Montpellier Medical
ICU.
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