The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese Patients

Acute Kidney Injury Clinical Trial

Official title:

The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03408834
• Other study ID #: 15-823-16
• Status: Completed
• Phase: N/A
• First received: January 17, 2018
• Last updated: January 25, 2018
• Start date: January 2, 2016
• Est. completion date: October 2, 2017

Study information

• Verified date: January 2018
• Source: Ankara University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatin in renal ischemic injury, was used.

Description:

Our object in this study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatine in renal ischemic injury, was used.

Patients undergoing elective laparoscopic colorectal surgery, 18 to 75 years old, planned surgery duration longer than 2 hours, were included in this study. Patients were divided into 2 groups with respect to their fluid resuscitation, Group 1: goal directed fluid therapy via PVI monitoring Group 2: conventional fluid resuscitation. Blood samples were drawn from both groups for NGAL measurement before CO2 insufflation (T0), and at 6th(T1) and 12th(T2) hours after CO2 insufflation. At the end of the surgery, sugammadex was given to all patients for reversal of muscular blockade.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 29
• Est. completion date: October 2, 2017
• Est. primary completion date: September 2, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• laparoscopic surgery

• obese patient

Exclusion Criteria:

• patient refusal

• major comorbidity

• renal failure

• diabetes mellitus

Related Conditions & MeSH terms

• Acute Kidney Injury
• Laparoscopic Colorectal Surgery
• Wounds and Injuries

Intervention

Other:
• pulse variability index
fluid management with pulse variability index or conventional

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ankara University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnosis of acute kidney injury	following up diagnosis of acute kidney injury	postoperative 6 th hour