Acute Kidney Injury ,Laparoscopic Cholecystectomy Clinical Trial
Official title:
Incidence of Acute Kidney Injury After Laparoscopic Cholecystectomy
The aim of this study is to establish AKI incidence in patients who are undergoing laparoscopic cholecystectomy and to identify the potential risk factors associated with the development of AKI.
Introduction: Laparoscopic procedure produces adverse effects on splanchnic organs.
Pneumoperitoneum is a non-physiologic condition that causes a higher intra-abdominal pressure
(IAP) and is associated with significant direct and indirect effects on renal physiology.
Aim of the study:
To establish AKI incidence in patients who are undergoing laparoscopic cholecystectomy.
To identify the potential risk factors associated with the development of AKI. To establish
the relationship between the IAP during the procedure and the AKI incidence.
Study Design:
Study population: A single center prospective cohort study will be conducted. 100 patients
undergoing elective laparoscopic cholecystectomy in the Galilee Medical Center will be
included.
Inclusion criteria: age > 18 years, able to sign the consent form, stable kidney function.
Exclusion criteria: end stage renal disease, acute kidney injury or need of dialysis three
months prior the procedure, acute infection, acute inflammation, BMI > 40, malignancy and
pregnancy.
The diagnosis of AKI will be made based on Kidney Disease Improving Global Outcomes (KDIGO)
Clinical Practice Guideline 2012, by comparing the baseline and post-operative serum
creatinine and cystatin C and monitoring urine output during the procedure and after the
procedure for 24 hours.
Data Analysis: Results will be presented as mean ± standard deviation for quantitative data.
A p value of <0.05 will be considered statistically significant.
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