Protective Effects of Edaravone Dexborneol

Status Recruiting

Clinical Trial Summary

The patients of acute ischemic stroke were divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The purpose of this study was to observe the changes of imaging and the improvement of NIHSS and mRS in different groups.

Clinical Trial Description

A total of 80 patients with acute ischemic stroke of middle cerebral artery were randomly divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The mismatch area between the low perfusion area of MRI 3D-ASL and the infarct area of DWI was defined as the ischemic penumbra, and the CBF perfusion pseudo color images with PLD of 1.5s and 2.5s were recorded. The above two CBF perfusion images were subtracted, and the residual area was quantitatively analyzed to reflect the establishment of collateral circulation. We aimed to observe whether there were differences in the improvement of ischemic penumbra and the establishment of collateral circulation between two groups after treatment. Besides, the improvment of NIHSS and mRS was also observed in different periods. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05024526
Study type	Interventional
Source	Qianfoshan Hospital
Contact	Yu-Qing Fang, MD
Phone	+8618866883808
Email	perfectin2000@163.com
Status	Recruiting
Phase	N/A
Start date	April 1, 2021
Completion date	March 31, 2023

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