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Acute Ischemic Stroke clinical trials

View clinical trials related to Acute Ischemic Stroke.

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NCT ID: NCT05249920 Completed - Clinical trials for Acute Ischemic Stroke

Treatment of Acute Ischemic STroke With Edaravone Dexborneol II (TASTE-2)

Start date: March 18, 2022
Phase: Phase 3
Study type: Interventional

This study is a multicentre, randomized, double-blind, placebo parallel controlled, investigator-sponsored study that aims to investigate the efficacy and safety of Edaravone Dexborneol treatment in patients with acute ischemic stroke who had received early reperfusion therapy.

NCT ID: NCT05200728 Completed - Clinical trials for Acute Ischemic Stroke

The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese Volunteers

Start date: December 6, 2021
Phase: Phase 1
Study type: Interventional

This is a single-center, randomized, double-blind, placebo-controlled Phase I clinical study to evaluate the tolerability, safety, and pharmacokinetic characteristics of SIM1910-09 for injection after single/multiple dosing in healthy Chinese adult volunteers.

NCT ID: NCT05153655 Completed - Clinical trials for Acute Ischemic Stroke

Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy

PROTECT
Start date: December 15, 2021
Phase: N/A
Study type: Interventional

Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke. The purpose of this proof-of-concept study is to determine the safety and tolerability of ischemic post-conditioning in patients with acute ischemic stroke who are treated with mechanical thrombectomy.

NCT ID: NCT05122637 Completed - Clinical trials for Acute Ischemic Stroke

Feasibility Study of RapidPulseTM Aspiration System as Frontline Approach for Stroke Patients

RapidPulseFS
Start date: January 31, 2022
Phase: N/A
Study type: Interventional

A Feasibility Study to evaluate the initial safety and performance of the RapidPulseTM Aspiration System in the treatment of patients with Acute Ischemic Stroke (AIS) due to Large Vessel Occlusion (LVO).

NCT ID: NCT05122286 Completed - Clinical trials for Acute Ischemic Stroke

Randomized Study of Bailout Intracranial Angioplasty Following Thrombectomy for Acute Large Vessel Occlusion

ANGEL-REBOOT
Start date: December 19, 2021
Phase: N/A
Study type: Interventional

Unfavorable outcomes were associated with failed thrombectomy of acute large vessel occlusions (LVO). The failed thrombectomy rate was 12-41% reported in multiple randomized controlled trials (RCT). Possible reasons of failed thrombectomy included technical failure of access, failure of retrieving thrombus, thrombotic re-occlusion, and pre-existing intracranial atherosclerotic stenosis (ICAS). Several studies have been published on balloon dilation or permanent stenting as rescue approaches for failed thrombectomy in individual cases, but there is no evidence from RCTs regarding this topic. ANGEL-REBOOT aims to close this gap by performing a randomized study of bailout intracranial angioplasty (balloon dilation and/or stenting) for unsuccessful thrombectomy in LVO patients.

NCT ID: NCT04995757 Completed - Clinical trials for Acute Ischemic Stroke

CAPTURE Registration Trial of the Thrombectomy System for the Treatment of Acute Ischemic Stroke.

Start date: March 21, 2018
Phase: N/A
Study type: Interventional

As this will be a pre-market registration trial, in which devices will be used in accordance with appropriately labeled indications, pre-study notifications and approval requests will be addressed with CFDA. All trial results will be shared with CFDA.

NCT ID: NCT04980625 Completed - Clinical trials for Acute Ischemic Stroke

Safety and Efficacy of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke

Start date: July 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning combined with intravenous thrombolysis in treating acute ischemic stroke.

NCT ID: NCT04951518 Completed - Clinical trials for Acute Ischemic Stroke

VAN Assessment Tool in the Treatment of Acute Ischemic Stroke

Start date: October 22, 2020
Phase:
Study type: Observational [Patient Registry]

To investigate the reliability of VAN tool as administered by Emergency Medical Services personnel to predict presence of a large vessel occlusion in setting of cerebral ischemic infarction

NCT ID: NCT04797013 Completed - Clinical trials for Acute Ischemic Stroke

Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-Ⅱ

TRACE?
Start date: June 12, 2021
Phase: Phase 3
Study type: Interventional

A Phase Ⅲ, Multicenter, Prospective, Randomized, Open Label, Blinded-endpoint (PROBE) Controlled Trial of Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) for Injection Versus Alteplase for Acute Ischemic Stroke Within 4.5 Hours

NCT ID: NCT04749251 Completed - Clinical trials for Acute Ischemic Stroke

IDEAL Blood Pressure Management During Endovascular Therapy for Acute Ischemic Stroke

IDEAL
Start date: April 1, 2021
Phase: N/A
Study type: Interventional

The ideal blood pressure management strategy during endovascular therapy (EVT) for acute ischemic stroke has not been defined. The aim of this pilot randomized clinical trial is to determine whether randomization to a standard versus individual blood pressure management strategy during the EVT procedure is feasible.