Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04196322 |
| Other study ID # |
El Zaitoun Specialized Hospita |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 15, 2016 |
| Est. completion date |
November 12, 2017 |
Study information
| Verified date |
February 2021 |
| Source |
Ain Shams University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Background: Hyperglycemia is encountered in 20% to 40% of acute stroke patients, with or
without a pre-morbid diagnosis of diabetes mellitus. Hyperglycemia is a risk factor for
infarct expansion and poor outcome through the first 72 hours of onset in both diabetics and
non-diabetics patients. This study was done to evaluate the glycemic status after acute
ischemic stroke and assess its rule in influencing stroke outcome as regards the duration of
hospital stay, motor deficit and mortality.
Methods: This retrospective study was conducted in Elzaiton specialized hospital from June
2016 to June 2017on 80 patients after approval of local medical ethical committee. Patients
with acute ischemic stroke without other major comorbidities within 24 hours of onset of
symptoms were included and divided into two groups, controlled group (Random blood suger not
more than 150 mg/dl) and uncontrolled group ( Random blood suger more than 150 mg/dl). All
patients were evaluated for GCS as a primary outcome and for hemorrhagic transformation,
hospital stay duration, mechanical ventilation, need for vasopressors,hospital stay and
mortality as secondary outcomes.
Description:
Patients and Methods This study was prospective study conducted in Elzaiton specialized
hospital and Ain Shams University from june2016 to June 2017on 80 patients after approval of
local medical ethical committee
All patients was subjected to the following
1. Full clinical history …age, sex, weight and medical history
2. GCS and motor deficit
3. Random blood glucose level at admission and 4-6 times daily during hospital stay
4. HbA1c on admission
5. Hemodynamic monitoring
6. Duration of hospital stay
7. Thirty day mortality
8. Other laboratory investigation to rule out other similar cause
9. Follow up hemorrhagic transformation Study tools: Patients with acute ischemic stroke
without other major comorbidities within 24 hours of onset of symptoms will be
evaluated.
On ICU admission the random blood sugar was recorded and categorized to less than 150mg/dl
(accepted) and more than 150mg/dl(not controlled). Also serial Random blood sugar daily was
recorded and categorized to accepted or good control if less than 150mg/dl and not controlled
if more than 150mg/dl.
Patients were divided into 2 groups Patients with accepted random blood sugar at admission
and controlled blood sugar during hospital stay.
Patients with increased random blood sugar at admission and poor blood sugar control during
hospital stay.
These data were collected and patients were observed as regards duration of hospital
stay,hemorrhagic transformation, hospital stay duration and 30-days mortality
