Acute Heart Failure Clinical Trial
— EPPICAOfficial title:
Interest of Lung Ultrasound (LUS) in Therapeutic Adaptation of Patients Hospitalized in Medical Department for Acute Heart Failure (AHF).
Evaluate lung ultrasound aspect according to diuretics dosage evolution in patients hospitalized for acute heart failure.
Status | Not yet recruiting |
Enrollment | 94 |
Est. completion date | October 2021 |
Est. primary completion date | May 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Acute heart failure diagnosed by a senior physician in the medical department, with a confirmation of a second senior physician. - Hospitalised in the medical department. - No objection from the patient of his trusted person. Exclusion Criteria: - Administrative supervision or deprived of their liberty - Pulmonary conditions distracting lung ultrasound (pneumonectomy, pulmonary fibrosis) - Chronically dialysed |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Grenoble |
Coiro S, Rossignol P, Ambrosio G, Carluccio E, Alunni G, Murrone A, Tritto I, Zannad F, Girerd N. Prognostic value of residual pulmonary congestion at discharge assessed by lung ultrasound imaging in heart failure. Eur J Heart Fail. 2015 Nov;17(11):1172-81. doi: 10.1002/ejhf.344. Epub 2015 Sep 29. — View Citation
Gargani L, Pang PS, Frassi F, Miglioranza MH, Dini FL, Landi P, Picano E. Persistent pulmonary congestion before discharge predicts rehospitalization in heart failure: a lung ultrasound study. Cardiovasc Ultrasound. 2015 Sep 4;13:40. doi: 10.1186/s12947-015-0033-4. — View Citation
Öhman J, Harjola VP, Karjalainen P, Lassus J. Focused echocardiography and lung ultrasound protocol for guiding treatment in acute heart failure. ESC Heart Fail. 2018 Feb;5(1):120-128. doi: 10.1002/ehf2.12208. Epub 2017 Sep 28. — View Citation
Platz E, Merz AA, Jhund PS, Vazir A, Campbell R, McMurray JJ. Dynamic changes and prognostic value of pulmonary congestion by lung ultrasound in acute and chronic heart failure: a systematic review. Eur J Heart Fail. 2017 Sep;19(9):1154-1163. doi: 10.1002/ejhf.839. Epub 2017 May 30. Review. — View Citation
Rusu DM, Siriopol I, Grigoras I, Blaj M, Ciumanghel AI, Siriopol D, Nistor I, Onofriescu M, Sandu G, Cobzaru B, Scripcariu DV, Diaconu O, Covic AC. Lung Ultrasound Guided Fluid Management Protocol for the Critically Ill Patient: study protocol for a multi-centre randomized controlled trial. Trials. 2019 Apr 25;20(1):236. doi: 10.1186/s13063-019-3345-0. — View Citation
Volpicelli G, Caramello V, Cardinale L, Mussa A, Bar F, Frascisco MF. Bedside ultrasound of the lung for the monitoring of acute decompensated heart failure. Am J Emerg Med. 2008 Jun;26(5):585-91. doi: 10.1016/j.ajem.2007.09.014. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Lung ultrasound aspect according to diuretics dosage evolution. | B-lines number on LUS | LUS will be performed daily during the whole hospitalisation length (on average 7 days). | |
Secondary | Lung ultrasound aspect according to clinical signs of acute heart failure (crackling auscultation or lower limbs edema) | B-lines number on LUS | LUS and clinical examination will be performed daily during the whole hospitalisation length (on average 7 days). | |
Secondary | Lung ultrasound aspect according to acute kidney injury (based on plasmatic creatinine levels). | B-lines number on LUS | LUS will be performed daily during the whole hospitalisation length (on average 7 days). Plasmatic creatinine measure will be performed at least weekly. | |
Secondary | Lung ultrasound aspect according to early prognosis (re-hospitalisation or mortality within 30 days after discharge) | B-lines number on LUS | LUS will be performed daily during the whole hospitalisation length (on average 7 days). Patient will be called 30 days after discharge. | |
Secondary | Feasibility of daily LUS in medical department. | Number of LUS performed compared to number of hospitalisation days. | LUS will be performed daily during the whole hospitalisation length (on average 7 days). | |
Secondary | Interest of LUS compared to clinical examination at discharge. | B-lines at discharge compared to clinical signs of acute heart failure. | LUS and clinical examination will be performed daily during the whole hospitalisation length (on average 7 days). |
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