MRI Assessment of Pulmonary Edema in Acute Heart Failure — MAP-AHF  

Acute Heart Failure Clinical Trial

Official title: MRI Assessment of Pulmonary Edema in Acute Heart Failure

Status Recruiting

Clinical Trial Summary

Researchers are testing a more accurate way to measure how much fluid is in the lungs (also called pulmonary edema, or "increased lung water") in people with Heart Failure (HF) using MRI (Magnetic Resonance Imaging). There is little known about the exact level of lung water in patients with AHF or how these levels change from the time of hospital admission to discharge. The purpose of this research study is to measure the lung water in patients hospitalized for HF, to determine the change in lung water over the course of hospitalization and treatment, and to find out if lung water levels can predict if patients are higher or lower risk for returning to the hospital or dying from heart failure.

Clinical Trial Description

Heart failure is a condition where the heart is unable to pump enough blood to meet the body's needs and Acute Heart Failure is a sudden worsening of this condition. It is associated with many symptoms but most commonly includes shortness of breath due to pulmonary edema (or increased "lung water"). A physical exam and chest x-ray are commonly used to diagnose AHF and estimate the amount of increased lung water in patients with AHF. This study will use images from MRI (Magnetic Resonance Imaging) scans to obtain a more accurate measurement of the increased lung water in AHF patients. Lung water will be measured via MRI at hospital admission and discharge to find out the change in lung water over the course of hospitalization and treatment. The investigators will collect NT-proBNP and perform a chest x-ray upon hospital admission and again upon discharge, if not already done as part of usual care. The investigators will follow medical records for up to 5 years after hospitalization to see if the accurate lung water measurements obtained in hospital can predict long term outcomes. This is a multi-centre project and a total of 300 patients will be recruited to participate. ;

Related Conditions & MeSH terms

• Acute Heart Failure
• Edema
• Heart Failure
• Pulmonary Edema
• Pulmonary Edema With Heart Failure

• NCT number: NCT03999138
• Study type: Observational
• Source: University of Alberta
• Contact: Ian Paterson, MD
• Phone: 613-696-7267
• Email: DPaterson@ottawaheart.ca
• Status: Recruiting
• Start date: January 2, 2019
• Completion date: June 1, 2024