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BLeeding Events and Maintenance DoSe of PraSugrel — BLESS  

Acute Coronary Syndrome Clinical Trial

Official title:
Bless Study (BLeeding Events and Maintenance DoSe of PraSugrel)

Clinical Trial Summary

Aim: to verify if after the acute phase of ACS acute coronary syndrome (1-months), from 1 to 12 months the reduction of maintenance dose of prasugrel from 10 mg to 5 mg/day may reduce the bleeding events (5 mg vs 10 mg). All patients will be treated with 325 mg of aspirin followed by a maintenance dosage of 100 mg of aspirin for at least 1 year. At baseline (after 60 mg loading dose of prasugrel) and after 1 month (7 days after the randomization at 10 or 5 mg of prasugrel) all patients will undergo light transmittance aggregometry (LTA) test to evaluate residual platelet reactivity (pharmacodynamic effects).

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01790854
Study type Interventional
Source Careggi Hospital
Contact
Status Terminated
Phase Phase 4
Start date November 2012
Completion date October 2014
View Details
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