Acute Coronary Syndrome Clinical Trial
Official title:
African-American Pharmacogenetics
This is a genetic and platelet reactivity study of African-American versus Caucasian patients undergoing percutaneous coronary intervention and receiving clopidogrel or prasugrel. The investigators aim is twofold: to describe differences in allele frequencies between African-Americans and Caucasians, and to explore associations of platelet reactivity and genetic polymorphisms in these two groups.
The investigators propose a pharmacogenetic cohort study of 100 African-American versus 100
Caucasian patients presenting with an acute coronary syndrome, receiving clopidogrel or
prasugrel and undergoing PCI. The study will have four arms: African-American on
clopidogrel; African-American on prasugrel; Caucasian on clopidogrel; and Caucasian on
prasugrel. All patients will undergo genotyping and platelet reactivity testing with the
VerifyNow P2Y12 assay, at least 6 hours after receiving a thienopyridine loading dose, but
before hospital discharge. All patients will be treated with aspirin 325 mg/day as well.
Race determination will be based on a patient's self-report, but patients enrolled in the
trial must also report that all four of their grandparents were of the same race as theirs.
Other races (Asian, Native American, et al) will be excluded from this study.
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Observational Model: Cohort, Time Perspective: Prospective
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