Acute Coronary Syndrome Clinical Trial
Official title:
High Sensitive Cardiac Troponin T for Early Prediction of Evolving Non-ST Segment Elevation Myocardial Infarction in Patients With Suspected Acute Coronary Syndrome and Negative Troponin Result on Admission
BACKGROUND: We sought to determine the diagnostic value of the new TnThs assay for early
detection of evolving non-STEMI in patients with acute coronary syndrome and a negative 4th
generation cTnT result on admission.
METHODS: We evaluated several statistical patterns of blood results of TnT hs and cTnT of
115 patients and calculated necessity of prediction of evolving non-STEMI within 6 hours.
RESULTS: Based on the results of the 4th generation cTnT assay, an evolving non-STEMI was
diagnosed in 26 patients, 31 were classified as unstable angina. The TnThs lead to an
increase of non-STEMI diagnosis as compared to the 4th generation assay. We could calculate
increased sensitivities for earlier detection of evolving non-STEMI from 61.5% on admission
to 90.9% within 3 hours and 100% within 6 hours compared to cTnT.
CONCLUSIONS: The TnThs assay enables earlier detection of non-STEMI and allows
identification of an additional percentage of cases with non-STEMI previously classified as
unstable angina.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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