Acute Anterior Wall Myocardial Infarction Clinical Trial
Official title:
Autologous Stem Cell Transplantation in Acute Myocardial Infarction
Objectives
Intracoronary transplantation of different cell populations have been used in acute
myocardial infarction (AMI) with promising results. The primary objective of the ASTAMI
study is to test whether intracoronary transplantation of autologous mononuclear bone marrow
cells (mBMC) improve left ventricular ejection fraction (LVEF) after anterior wall AMI.
Design
The ASTAMI study is a randomized, controlled, prospective study. One hundred patients with
acute anterior wall ST-elevation myocardial infarction (STEMI) treated with acute PCI are
randomized in a 1:1 way to either intracoronary transplantation of autologous mBMC 5-8 days
after PCI or to control. Left ventricular function, exercise capacity, biochemical status,
functional class, quality of life and complications are validated at baseline and during a
12-month follow up.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment